The Lancet  
Jul 23, 2011  Volume 378  Number 9788  p289 – 372
http://www.thelancet.com/journals/lancet/issue/current

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The vaccine paradox
Richard Horton, Pamela Das

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The next decade will likely bring astonishing successes in vaccine biology, discovery, and delivery. Justifiable confidence in this proposition led the Bill & Melinda Gates Foundation last year to pledge US$10 billion to a new Decade of Vaccines. For the world’s largest and most influential health foundation, vaccines are the number one priority. The foundation estimates that if vaccine coverage could be scaled up to 90%, the lives of 7·6 million children younger than 5 years could be saved between 2010 and 2019.