Science        
7 October 2011 vol 334, issue 6052, pages 1-144
http://www.sciencemag.org/current.dtl

EDITORIAL:
Genomics Is Not Enough
Aravinda Chakravarti
Science 7 October 2011: 15.

Next week, the international congress of human genetics convenes in Montreal, where genomic science, its technologies, genetic disease, and personalized medicine will be discussed. Translating current knowledge into medical practice is an important goal for the public who support medical research, and for the scientists and clinicians who articulate the critical research needs of our time. However, despite innumerable successful gene discoveries through genomics, a major impediment is our lack of knowledge of how these genes affect the fundamental biological mechanisms that are dysregulated in disease. If genomic medicine is to prosper, we need to turn our attention to this gaping hole.