Vaccine
http://www.sciencedirect.com/science/journal/0264410X
Volume 30, Issue 3 pp. 499-684 (11 January 2012)

Regular Papers
Effectiveness of rotavirus vaccines in preventing cases and hospitalizations due to rotavirus gastroenteritis in Navarre, Spain
Pages 539-543
Jesús Castilla, Xabier Beristain, Víctor Martínez-Artola, Ana Navascués, Manuel García Cenoz, Nerea Álvarez, Isabel Polo, Ana Mazón, Alberto Gil-Setas, Aurelio Barricarte

Abstract
Two rotavirus vaccines have been available since 2006. This study evaluates the effectiveness of these vaccines using a test-negative case–control design in Navarre, Spain. We included children 3–59 months of age who sought medical care for gastroenteritis and for whom stool samples were taken between January 2008 and June 2011. About 9% had received the pentavalent vaccine (RotaTeq) and another 8% received the monovalent vaccine (Rotarix). Cases were the 756 children with confirmed rotavirus and controls were the 6036 children who tested negative for rotavirus. Thirty-five percent of cases and 9% of controls had required hospitalization (p < 0.0001). The adjusted effectiveness of complete vaccination was 78% (95% CI: 68–85%) in preventing rotavirus gastroenteritis and 83% (95% CI: 65–93%) in preventing hospitalization for rotavirus gastroenteritis. No differences between the two vaccines were detected (p = 0.4523). Both vaccines were highly effective in preventing cases and hospital admissions in children due to rotavirus gastroenteritis.