Controlling Dengue with Vaccines in Thailand

PLoS Neglected Tropical Diseases
October 2012
http://www.plosntds.org/article/browseIssue.action

Controlling Dengue with Vaccines in Thailand
Dennis L. Chao, Scott B. Halstead, M. Elizabeth Halloran, Ira M. Longini Jr.

Author Summary 
An estimated 40% of the world’s population is at risk of infection with dengue, a mosquito-borne disease that can lead to hospitalization or death. Dengue vaccines are currently being tested in clinical trials and at least one product will likely be available within a couple of years. Before widespread deployment, one should plan how best to use limited supplies of vaccine. We developed a mathematical model of dengue transmission in semi-rural Thailand to help evaluate different vaccination strategies. Our modeling results indicate that children should be prioritized to receive vaccine to reduce dengue-related morbidity, but adults will also need to be vaccinated if one wants to eliminate local dengue transmission. Dengue is a challenging disease to study because of its four interacting serotypes, seasonality of its transmission, and pre-existing immunity in a population. Models such as this one are useful coherent framework for synthesizing these complex issues and evaluating potential public health interventions such as mass vaccination.