How cost effective is universal varicella vaccination in developing countries? A case-study from Colombia

Vaccine
Volume 31, Issue 2, Pages 279-438 (2 January 2013)
http://www.sciencedirect.com/science/journal/0264410X

How cost effective is universal varicella vaccination in developing countries? A case-study from Colombia
Original Research Article
Pages 402-409
Angel Paternina-Caicedo, Fernando De la Hoz-Restrepo, Oscar Gamboa-Garay, Carlos Castañeda-Orjuela, Martha Velandia-González, Nelson Alvis-Guzmán

Abstract
Objective
Varicella vaccination has not been introduced worldwide, especially in developing countries. The present study assesses the potential epidemiological and economic impact of one-dose and two-dose varicella vaccination schemes in Colombia, a south American upper middle-income country.

Methods
A decision-tree based model was developed. Varicella cases were estimated based on previous reports of seropositivity within the country. Cost per life-year gained (LYG) was the main outcome measure. Costs from the health care system perspective were expressed in 2008 American dollars. Deterministic and probabilistic sensitivity analyses were performed.

Results
In Colombia, there would be 700,197 varicella cases in an average year plus 60 yearly deaths without vaccination. It was estimated that health care costs for all cases during 30 years period could be around US $88,734,735 (with discount). Cost per LYG of one-dose vaccination was US $2519 and using a two-dose scheme was US $5728.