September 4, 2013, Vol 310, No. 9
Research Letter | September 4, 2013
Thirty-Year Outcomes of the National Hepatitis B Immunization Program in Taiwan
Chun-Ju Chiang, PhD1; Ya-Wen Yang, MSc2; San-Lin You, PhD3; Mei-Shu Lai, MD, PhD1; Chien-Jen Chen, ScD3
[+] Author Affiliations
JAMA. 2013;310(9):974-976. doi:10.1001/jama.2013.276701.
Initial content per JAMA convention
Hepatitis B virus (HBV) infection causes infant fulminant hepatitis (IFH), and chronic HBV infection may progress to chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Taiwan launched a nationwide HBV immunization program for newborns in July 1984,1 which has successfully lowered the prevalence of chronic HBV carriers, incidence of HCC, and mortality of IFH in vaccinated birth cohorts.2- 4 The mortality of CLD before and after HBV immunization has never been examined. We assessed the 30-year outcomes of the immunization program…