Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention

Vaccines — Open Access Journal
(Accessed 15 February 2014)
http://www.mdpi.com/journal/vaccines

Review
Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention
by Lucia H. Lee, Xin-Xing Gu and Moon H. Nahm
Vaccines 2014, 2(1), 112-128; doi:10.3390/vaccines2010112 – published online 14 February 2014
Abstract: Seven-valent pneumococcal conjugate vaccine (PCV7) introduction and routine pediatric use has substantially reduced the burden of Streptococcus pneumoniae disease worldwide. However, a significant amount of disease burden, due to serotypes not contained in PCV7, still exists globally. A newly recognized serotype, 6C, was until recently, identified and reported as serotype 6A. This review summarizes the serotype epidemiology of pneumococcal disease pre- and post-introduction of PCV7, available post-marketing surveillance data following the introduction of higher valency pneumococcal vaccines (PCV10, PCV13) and future prospects for the development of new pneumococcal vaccines.