New England Journal of Medicine
March 30, 2017 Vol. 376 No. 13
From Trial to Target Populations — Calibrating Real-World Data
Mehdi Najafzadeh, Ph.D., and Sebastian Schneeweiss, M.D., Sc.D.
N Engl J Med 2017; 376:1203-1205 March 30, 2017 DOI: 10.1056/NEJMp1614720
One difficulty in translating clinical trial findings for target patient populations is that risk factors in trials and electronic health care databases are measured in different ways. We therefore need a way to calibrate our measurements between these two data worlds.