Cohort Profile: The Kilifi Vaccine Monitoring Study

International Journal of Epidemiology
Volume 46, Issue 3, 1 June 2017

Cohort Profiles
Cohort Profile: The Kilifi Vaccine Monitoring Study
Ifedayo MO Adetifa; Tahreni Bwanaali; Jackline Wafula; Alex Mutuku; Boniface Karia
International Journal of Epidemiology, Volume 46, Issue 3, 1 June 2017, Pages 792–792h,
…The Kenya Medical Research Institute-Wellcome Trust Research Programme (KWTRP) in Kilifi set up the Haemophilus influenzae type b (Hib) conjugate vaccine effectiveness study in 2000. It was further expanded in 2008 with addition of the real-time vaccine monitoring component, in anticipation of the introduction of pneumococcal conjugate vaccine (PCV) in Kenya. The objective of the Kilifi Vaccine Monitoring Study (KiVMS), a long-term continuous cohort study, is to investigate effectiveness, impact, coverage, safety and indirect vaccine effects by recruiting birth cohorts as well as cohorts of older children and adults where applicable, within a well-characterized population and area. In addition, KiVMS is used to explore the determinants of vaccine coverage and acceptability in the population. Built on the platform of a Health and Demographic Surveillance System (HDSS), KiVMS integrates morbidity surveillance systems at the County Department of Health (CDOH), Kilifi, and a population-based, computerized information system for collecting vaccination data. Therefore it has the following essential attributes: continuously updated demographic data from the population of interest (e.g. births, deaths and migration); and complete and accurate vaccination records for the catchment population. Vaccine information systems are rare in tropical Africa..