Platform technologies for modern vaccine manufacturing

Vaccine
Volume 35, Issue 35, Part A, Pages 4451-4490 (16 August 2017)
http://www.sciencedirect.com/science/journal/0264410X/35/35/part/PA?sdc=1
10th Vaccine Congress

Platform technologies for modern vaccine manufacturing
Original Research Article
Pages 4480-4485
Hayley K. Charlton Hume, Linda H.L. Lua
Abstract
Improved understanding of antigenic components and their interaction with the immune system, as supported by computational tools, permits a sophisticated approach to modern vaccine design. Vaccine platforms provide an effective tool by which strategically designed peptide and protein antigens are modularized to enhance their immunogenicity. These modular vaccine platforms can overcome issues faced by traditional vaccine manufacturing and have the potential to generate safe vaccines, rapidly and at a low cost. This review introduces two promising platforms based on virus-like particle and liposome, and discusses the methodologies and challenges.