Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control

New England Journal of Medicine
September 7, 2017  Vol. 377 No. 10
http://www.nejm.org/toc/nejm/medical-journal

Original Article
Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control
Cristina V. Cardemil, M.D., M.P.H., Rebecca M. Dahl, M.P.H., Lisa James, R.N., M.S.N., Kathleen Wannemuehler, Ph.D., Howard E. Gary, Ph.D., Minesh Shah, M.D., M.P.H., Mona Marin, M.D., Jacob Riley, M.S., Daniel R. Feikin, M.D., Manisha Patel, M.D., and Patricia Quinlisk, M.D., M.P.H.
N Engl J Med 2017; 377:947-956 September 7, 2017 DOI: 10.1056/NEJMoa1703309
Conclusions
Students who had received a third dose of MMR vaccine had a lower risk of mumps than did those who had received two doses, after adjustment for the number of years since the second dose. Students who had received a second dose of MMR vaccine 13 years or more before the outbreak had an increased risk of mumps. These findings suggest that the campaign to administer a third dose of MMR vaccine improved mumps outbreak control and that waning immunity probably contributed to propagation of the outbreak. (Funded by the Centers for Disease Control and Prevention.)