The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People

Journal of Infectious Diseases
Volume 216, Issue 4   15 August 2017
https://academic.oup.com/jid/issue

VIRUSES
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The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People
Melissa K Andrew; Vivek Shinde; Lingyun Ye; Todd Hatchette; François Haguinet
The Journal of Infectious Diseases, Volume 216, Issue 4, 15 August 2017, Pages 405–414, https://doi.org/10.1093/infdis/jix282
Frailty has important impacts on influenza vaccine effectiveness (VE). Here, frailty was the most important confounder of VE, and not accounting for frailty underestimated VE. VE was high in nonfrail older adults, but diminished with increasing frailty.