Intention to accept pertussis vaccine among pregnant women in Karachi, Pakistan

Vaccine
Volume 35, Issue 40, Pages 5309-5434 (25 September 2017)
http://www.sciencedirect.com/science/journal/0264410X/35/40?sdc=1

Intention to accept pertussis vaccine among pregnant women in Karachi, Pakistan
Original Research Article
Pages 5352-5359
Mariam Siddiqui, Afshin Alaf Khan, Aiden Kennedy Varan, Alejandra Esteves-Jaramillo, Shazia Sultana, Asad S. Ali, Anita K.M. Zaidi, Saad B. Omer
Abstract
Background
Maternal immunization against pertussis is a potential strategy to protect young infants from severe disease. We assessed factors associated with intention to accept pertussis vaccination among pregnant women in Karachi, Pakistan.
Methods
We conducted a cross-sectional survey between May and August 2013 in pregnant women who visited healthcare centers in urban slums of Karachi city. Women completed a survey examining socio-demographic factors, vaccination history, knowledge on pertussis disease, perception of vaccine recommendation sources, and potential influences on vaccine decision-making.
Results
Of the 283 participants, 259 (92%) provided their intention to either accept or decline pertussis vaccination. Eighty-three percent women were willing to accept the pertussis vaccine if offered during pregnancy. About half (53%) of the participants had ever heard of pertussis disease. Perceptions of pertussis vaccine efficacy, safety, and disease susceptibility were strongly associated with intention to accept pertussis vaccine (p < 0.01). Healthcare providers, Ministry of Health, and mass media were considered as highly reliable sources of vaccine recommendation and associated with intention to accept antenatal pertussis vaccination (p < 0.001). Healthcare provider recommendation was a common reason cited by respondents for pregnant women to accept antenatal pertussis vaccination (p = 0.0005). However, opinion of primary decision-makers in the family (husbands and in-laws) was a crucial reason cited by respondents for pregnant women to reject pertussis vaccination in pregnancy (p = 0.003).
Conclusion
Antenatal pertussis vaccination initiatives in South Asia should strongly consider inclusion of family members, healthcare providers, national health ministries, and mass media to help implement new vaccination programs.