Variation in loss of immunity shapes influenza epidemics and the impact of vaccination

BMC Infectious Diseases
http://www.biomedcentral.com/bmcinfectdis/content
(Accessed 23 September 2017)

Research Article
Variation in loss of immunity shapes influenza epidemics and the impact of vaccination
Protective antibody immunity against the influenza A virus wanes in 2–7 years due to antigenic drift of the virus’ surface proteins. The duration of immune protection is highly variable because antigenic evolu… The models illustrate that variation in the duration of immunity impacts the long-term effectiveness of vaccination, and that vaccine effectiveness cannot be judged for each year in isolation. Our findings have implications for vaccination strategies that aim to maximize the vaccination coverage while extending the age range of persons eligible for vaccination.
Rutger G. Woolthuis, Jacco Wallinga and Michiel van Boven
BMC Infectious Diseases 2017 17:632
Published on: 19 September 2017