Vaccine – Volume 35, Issue 41, Pages 5435-5510 (4 October 2017)

Vaccine
Volume 35, Issue 41, Pages 5435-5510 (4 October 2017)
http://www.sciencedirect.com/science/journal/0264410X/35/41?sdc=1
New Technologies, New Vaccines

Edited by Stephen J. Streatfield, Jerzy Karczewski and Vidadi Yusibov
Original Research Article
Vaccine development for emerging virulent infectious diseases
Pages 5437-5443
Joel N. Maslow
Abstract
The recent outbreak of Zaire Ebola virus in West Africa altered the classical paradigm of vaccine development and that for emerging infectious diseases (EIDs) in general. In this paper, the precepts of vaccine discovery and advancement through pre-clinical and clinical assessment are discussed in the context of the recent Ebola virus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Zika virus outbreaks. Clinical trial design for diseases with high mortality rates and/or high morbidity in the face of a global perception of immediate need and the factors that drive design in the face of a changing epidemiology are presented. Vaccines for EIDs thus present a unique paradigm to standard development precepts.

Original Research Article
Characterization of human monoclonal antibodies that neutralize multiple poliovirus
serotypes
Pages 5455-5462
Rama Devudu Puligedda, Diana Kouiavskaia, Fetweh H. Al-Saleem, Chandana Devi Kattala, Usman Nabi, Hamid Yaqoob, V. Sandeep Bhagavathula, Rashmi Sharma, Konstantin Chumakov, Scott K. Dessain