Development of Zika Virus Vaccines

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 20 January 2018)
Open Access  Review

Development of Zika Virus Vaccines
by Huda Makhluf and Sujan Shresta
Vaccines 2018, 6(1), 7; doi:10.3390/vaccines6010007 – 18 January 2018
Abstract
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes. Many of these approaches have leveraged lessons learned from past experience with Dengue and other flavivirus vaccines