Reports/Research/Analysis/Commentary/Conferences/Meetings/Book Watch/Tenders

Reports/Research/Analysis/Commentary/Conferences/Meetings/Book Watch/Tenders
Vaccines and Global Health: The Week in Review has expanded its coverage of new reports, books, research and analysis published independent of the journal channel covered in Journal Watch below. Our interests span immunization and vaccines, as well as global public health, health governance, and associated themes. If you would like to suggest content to be included in this service, please contact David Curry at:
Vaccine Confidence Project  [to 3 March 2018]
Confidence Commentary
To wipe out measles, governments must regain social trust
Heidi Larson | 28 Feb, 2018
To wipe out measles, governments must regain social trust
Published in the Financial Times</em  
Europe’s measles outbreaks have made headlines in recent weeks, with more than 21,000 cases, hundreds of hospitalisations and 35 deaths reported in 2017. The World Health Organization called the numbers “a tragedy we simply cannot accept”.While some of these patients were too young to be vaccinated, or had other health concerns that made vaccination inadvisable, the majority of cases are of people who shunned immunisation. Among those, some cited safety fears and others ideological reasons, or simply their distrust in “the system”.

This week marks 20 years since Andrew Wakefield published his faulty research linking the measles, mumps, and rubella, or MMR, vaccine to autism, sparking a public panic. Most people who still cling to the debunked myth have never read Mr Wakefield’s article, but the dangerous rumours it sparked have nevertheless gone global.  The UK’s immunisation coverage rates have only recently recovered to their pre-autism-scare levels. The rest of the world remains sceptical.
Internationally, more people are refusing the vaccine. In south India last year, Facebook and WhatsApp campaigns against the measles vaccine cited the autism connection, prompting a drop in vaccine acceptance. In Malaysia, the ministry of health has worked to overcome public anxiety as vaccine refusal rises.

But the measles outbreaks in Europe cannot be blamed on the autism rumour alone. Reluctance and refusal to vaccinate reflects deeper issues around public trust in government, anger about vaccine mandates and resistance to medical treatments that are perceived as “not natural”. Spurious claims spread quickly via social media.

Last week, Italians marched in Rome to protest against fascism, neo-racism, labour reforms and mandatory vaccines. In the Philippines, the measles vaccine suffered collateral damage from public distrust around the dengue fever vaccine Dengvaxia. After its manufacturer, Sanofi Pasteur, reported findings that Dengvaxia provides valuable protection for some, but higher risks for others, fears spiralled into a general distrust of the country’s immunisation programme. Some parents refused measles vaccinations for their children and outbreaks of the disease increased.

In Brazil in 2016, when links between the Zika virus and microcephaly were being investigated, rumours began to swirl that the MMR vaccine was the cause of the birth defect, reflecting entrenched distrust in the state. Governments are at the heart of every element of vaccination policy, from regulation of safety controls to approving immunisation schedules. So gaining public trust will not only be key to the sustainability of routine immunisation programmes, but especially critical in the face of epidemic threats.

This year marks the 100th anniversary of the 1918 Spanish flu pandemic that infected 500m people, causing debilitating illness and killing between 40m and 50m. The threat is still present: the World Bank estimates that, in addition to millions of deaths, devastating illness and social disruption, the annual global cost of moderately severe to severe pandemics is roughly $570bn, or 0.7 per cent of global income. In 2009, during the swine flu pandemic of the H1N1 influenza virus, poor public co-operation and low acceptance of the vaccine was a wake-up call. The public might fall for faulty science, but the more worrying trend in 2009 was the lack of civic responsibility and co-operation.

Governments should see in this an urgent need for a new social contract. The long cherished dream of eliminating measles is not an impossible task. Every country that achieved the goal would also demonstrate the strength of its citizens’ trust — a measure of its ability to manage future threats.


Stakeholders meeting on maternal interventions vigilance: safety monitoring and surveillance in vaccine and other research settings
Domaine de Penthes
Geneva, Switzerland
20-21 November 2017
World Health Organization – 2018 :: 45 pages  WHO/EMP/2018.1
There is increasing evidence that maternal immunization has the potential to improve health outcomes for both mothers and their babies. As a number of promising vaccines are in the process of development, there is need to ensure that mechanisms are in place for appropriate safety monitoring. The Stakeholders Meeting on Maternal Interventions Vigilance was organized by the World Health Organization (WHO) to assess current vigilance methods for maternal immunization and other interventions in pregnancy and to propose a roadmap for harmonization of vigilance across programmes.

In background information for the meeting, WHO noted that safety monitoring of vaccines administered during pregnancy will require “enhanced vigilance mechanisms and standardized case definitions of key events in pregnant women and newborns”. However, there are numerous medical interventions during pregnancy and early childhood, requiring that immunization and safety monitoring of vaccines should be harmonized with a range of methods by a range of stakeholders.

The Stakeholders Meeting on Maternal Interventions Vigilance was convened as a result of collaboration between four technical departments of WHO (Immunization, Vaccines and Biologicals; Essential Medicines and Health Products; Reproductive Health and Research; and Maternal, Newborn, Child and Adolescent Health). Those core organizers were also guided by advice from a further six WHO departments, covering all health issues relating to pregnancy and newborn health.1

Specifically, the meeting set out to:
:: review current methods or methodologies to monitor outcomes of maternal immunization and other interventions, with a particular focus on pharmacovigilance;
:: assess these vigilance methodologies and identify where harmonization is needed;
:: assess their global applicability for maternal immunization and other interventions;
:: propose coordination mechanisms and a roadmap to support their harmonization across programmes and partners working on improving pregnancy and early childhood health outcomes.