The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 3 March 2018)

Research Article
The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study
Flavio Finger, Enrico Bertuzzo, Francisco J. Luquero, Nathan Naibei, Brahima Touré, Maya Allan, Klaudia Porten, Justin Lessler, Andrea Rinaldo, Andrew S. Azman
| published 27 Feb 2018 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1002509
Cholera prevention and control interventions targeted to neighbors of cholera cases (case-area targeted interventions [CATIs]), including improved water, sanitation, and hygiene, oral cholera vaccine (OCV), and prophylactic antibiotics, may be able to efficiently avert cholera cases and deaths while saving scarce resources during epidemics. Efforts to quickly target interventions to neighbors of cases have been made in recent outbreaks, but little empirical evidence related to the effectiveness, efficiency, or ideal design of this approach exists. Here, we aim to provide practical guidance on how CATIs might be used by exploring key determinants of intervention impact, including the mix of interventions, “ring” size, and timing, in simulated cholera epidemics fit to data from an urban cholera epidemic in Africa.