New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data

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Vaccine
Volume 36, Issue 13  Pages 1711-1800 (20 March 2018)
https://www.sciencedirect.com/journal/vaccine/vol/36/issue/13

Review
New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data
Review article
Pages 1711-1719
Mohammadreza Shaghaghi, Saeed Soleyman-jahi, Hassan Abolhassani, Reza Yazdani, … Asghar Aghamohammadi
Abstract
Widespread administration of oral poliovirus vaccine (OPV) has decreased global incidence of poliomyelitis by ≈99.9%. However, the emergence of vaccine-derived polioviruses (VDPVs) is threatening polio-eradication program. Primary immunodeficiency (PID) patients are at higher risks of vaccine-associated paralytic poliomyelitis (VAPP) and prolonged excretion of immunodeficiency-associated VDPV (iVDPV).