Volume 36, Issue 13 Pages 1711-1800 (20 March 2018)
New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data
Mohammadreza Shaghaghi, Saeed Soleyman-jahi, Hassan Abolhassani, Reza Yazdani, … Asghar Aghamohammadi
Widespread administration of oral poliovirus vaccine (OPV) has decreased global incidence of poliomyelitis by ≈99.9%. However, the emergence of vaccine-derived polioviruses (VDPVs) is threatening polio-eradication program. Primary immunodeficiency (PID) patients are at higher risks of vaccine-associated paralytic poliomyelitis (VAPP) and prolonged excretion of immunodeficiency-associated VDPV (iVDPV).