Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 31 March 2018)

Open Access
Review
Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
by E. Bridie Clemens, Carolien van de Sandt, Sook San Wong, Linda M. Wakim and Sophie A. Valkenburg
Vaccines 2018, 6(2), 18; doi:10.3390/vaccines6020018 – 26 March 2018
Abstract
Next-generation vaccines that utilize T cells could potentially overcome the limitations of current influenza vaccines that rely on antibodies to provide narrow subtype-specific protection and are prone to antigenic mismatch with circulating strains. Evidence from animal models shows that T cells can provide