Statistics in Medicine: Multiplicity Considerations in Clinical Trials

New England Journal of Medicine
May 31, 2018  Vol. 378 No. 22
http://www.nejm.org/toc/nejm/medical-journal

Review Article
Statistics in Medicine: Multiplicity Considerations in Clinical Trials
A Dmitrienko and R.B. D’Agostino, Sr.
Making multiple comparisons increases the likelihood that a chance association could be interpreted as causal. A number of statistical approaches can facilitate the precise interpretation of clinical trial results.