Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled tria

BMJ Open
June 2018 – Volume 8 – 6
http://bmjopen.bmj.com/content/current

Global health
Protocol
Evaluation of different infant vaccination schedules incorporating pneumococcal vaccination (The Vietnam Pneumococcal Project): protocol of a randomised controlled trial (8 June, 2018)
WHO recommends the use of pneumococcal conjugate vaccine (PCV) as a priority. However, there are many countries yet to introduce PCV, especially in Asia. This trial aims to evaluate different PCV schedules and to provide a head-to-head comparison of PCV10 and PCV13 in order to generate evidence to assist with decisions regarding PCV introduction. Schedules will be compared in relation to their immunogenicity and impact on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae.
Beth Temple, Nguyen Trong Toan, Doan Y Uyen, Anne Balloch, Kathryn Bright, Yin Bun Cheung, Paul Licciardi, Cattram Duong Nguyen, Nguyen Thi Minh Phuong, Catherine Satzke, Heidi Smith-Vaughan, Thi Que Huong Vu, Tran Ngoc Huu, Edward Kim Mulholland