Keep off-target effects in focus

Nature Medicine
Volume 24 Issue 8, August 2018
https://www.nature.com/nm/volumes/24/issues/8

Editorial | 06 August 2018
Keep off-target effects in focus
Concerns about potential unintended DNA changes that might accidentally arise from CRISPR gene editing have emerged to varying degrees with the advent of the technology. As new therapies move from bench to bedside, scientists need to redouble their efforts to document the spectrum of these off-target effects while also acknowledging the reality that a certain degree of risk is embedded in many promising and successful medical therapies.