The Influenza Vaccine Mess

Journal of the Pediatric Infectious Diseases Society (JPIDS)
Volume 7, Issue 3, September 2018

On Vaccination
The Influenza Vaccine Mess
Stanley A Plotkin
Journal of the Pediatric Infectious Diseases Society, Volume 7, Issue 3, 17 August 2018, Pages 178–180,
By and large, we think of vaccines as highly efficacious, as has been shown in placebo-controlled trials and also by the decreasing incidence of the disease against which a vaccine has been developed. Not so with inactivated influenza vaccine, which we recommend each year for both children and adults but without expecting high efficacy. Indeed, we hope only for moderate efficacy under the conditions of a circulating influenza virus that has not changed substantially from the related strain that was included in the vaccine [1]. Moreover, the failure rate is augmented by the fact that current vaccines are aimed…