Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, CanadaA Canadian Immunization Research Network (CIRN) Study

JAMA Pediatrics
September 2018, Vol 172, No. 9, Pages 793-896
http://archpedi.jamanetwork.com/issue.aspx

Original Investigation
Effectiveness of Live Attenuated vs Inactivated Influenza Vaccines in Children During the 2012-2013 Through 2015-2016 Influenza Seasons in Alberta, CanadaA Canadian Immunization Research Network (CIRN) Study
Sarah A. Buchan, PhD; Stephanie Booth, MPH; Allison N. Scott, PhD; et al.
Key Points
Question
Does vaccine effectiveness differ between live attenuated influenza vaccine and inactivated influenza vaccine in children and adolescents?
Findings
This test-negative study compared health administrative data and laboratory test results on respiratory specimens from 10,169 children and adolescents across 4 influenza seasons and found no significant differences in the odds of influenza infection between children who received live attenuated and those who received inactivated influenza vaccine. The only exception was influenza B during the 2015-2016 season, for which live attenuated influenza vaccine provided better protection than inactivated influenza vaccine.
Meaning
These results support receipt of either live attenuated influenza vaccine or inactivated influenza vaccine in this age group.