India is committed to the elimination of measles and control of rubella and congenital rubella syndrome by 2020. Rubella infection during early pregnancy can result in serious consequences such as miscarriage, stillbirth, or a constellation of severe birth defects known as congenital rubella syndrome (CRS). The Government of India is committed to eliminate measles and control rubella and CRS by 2020. The Indian Council of Medical Research (ICMR) and the Indian Ministry of Health and Family Welfare (MoHFW) initiated laboratory-supported surveillance for CRS in five sentinel sites in November 2016. During the first eight months, surveillance identified more than 200 suspected CRS patients. About a third of the patients had laboratory-confirmed CRS. The experience gained during the first phase of surveillance will be useful in expanding the surveillance network; data generated will help monitor progress toward CRS control in India.