Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach

Journal of Virology
November 2018; Volume 92,Issue 21
http://jvi.asm.org/content/current

Vaccines and Antiviral Agents | Spotlight
Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach
Many flaviviruses are significant human pathogens that pose global threats to public health. Although licensed vaccines are available for yellow fever, Japanese encephalitis, tick-borne encephalitis, and dengue viruses, new approaches are needed to develop improved vaccines. Using dengue virus as a model, we developed a vaccine platform using a virion assembly-defective virus. We show that such an assembly-defective virus could be…
Chao Shan, Xuping Xie, Jing Zou, Roland Züst, Bo Zhang, Rebecca Ambrose, Jason Mackenzie, Katja Fink, Pei-Yong Shi