From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary
Current Topics in Medicinal Chemistry
(E-pub Abstract Ahead of Print)
Dengue fever: a worldwide threat An overview of the infection process, environmental factors for global outbreak, diagnostic platforms, and vaccine developments.
S Hosseini, J Oliva-Ramírez, P Vázquez-Villegas…
Current review article focuses on Dengue, which is one of the most fatal infectious illnesses and is considered to be a worldwide threat. The paper covers essential topics including an overview on neglected tropical diseases with specific emphasis on Dengue fever, mosquito’s cycle of life and mechanism of infection, adaptive response, and different stages in Dengue immunopathogenesis. The current work is also dedicated to the thorough study of Dengue outbreak across the globe with narrowed study to tropical and subtropical regions. Moreover, this review article demonstrates the correlation between the climate factors and Dengue incidence. Furthermore, we present an overview on the detection strategies of Dengue including the latest developments in commercial and non-commercial platforms. Several attempts in developing effective vaccine to protect individuals from Dengue infection and the stage of clinical trails are gathered in the present work as well. Future directions including bio-control are also discussed in this review article. In an overall view, effective management of Dengue is a multidisciplinary task that requires international involvement from different backgrounds and expertise to address this global concern. This review article briefly portrays some of these connecting areas across the disciplines while many other perspectives remain uncovered.
Volume 36, Issue 49 Pages 7439-7588 (26 November 2018)
Conflicts of interest and the (in)dependence of experts advising government on immunization policies
Jean-Christophe Bélisle-Pipon, Louise Ringuette, Anne-Isabelle Cloutier, Victoria Doudenkova, Bryn Williams-Jones
:: Immunization experts’ financial conflicts of interest (COI) may affect public trust.
:: (In)DepScale was developed for assessing experts’ level of (in)dependence.
:: Ad hoc experts have lower levels of independence than statutory members.
:: Most COIs are reported with companies with the highest vaccine sales.
:: (In)DepScale may help immunization committees to manage COIs.
There has been increasing attention to financial conflicts of interest (COI) in public health research and policy making, with concerns that some decisions are not in the public interest. One notable problematic area is expert advisory committee (EAC). While COI management has focused on disclosure, it could go further and assess experts’ degree of (in)dependence with commercial interests. We analyzed COI disclosures of members of Québec’s immunization EAC (in Canada) using (In)DepScale, a tool we developed for assessing experts’ level of (in)dependence. We found great variability of independence with industry and that companies with the highest vaccine sales were predominantly associated with disclosed COIs. We argue that EACs can use the (In)DepScale to better assess and disclose the COIs that affect their experts. Going forward our scale could help manage risk and select members who are less conflicted to foster a culture of transparency and trust in advisors and policy-makers.