WHO & Regional Offices [to 24 Nov 2018 ]

WHO & Regional Offices [to 24 Nov 2018 ]
21 November 2018
News Release
WHO and EU commit to work together to accelerate progress on health

19 November 2018
News Release
WHO and partners launch new country-led response to put stalled malaria control efforts back on track
Reductions in malaria cases have stalled after several years of decline globally, according to the new World malaria report 2018. To get the reduction in malaria deaths and disease back on track, WHO and partners are joining a new country-led response, launched today, to scale up prevention and treatment, and increased investment, to protect vulnerable people from the deadly disease.

For the second consecutive year, the annual report produced by WHO reveals a plateauing in numbers of people affected by malaria: in 2017, there were an estimated 219 million cases of malaria, compared to 217 million the year before. But in the years prior, the number of people contracting malaria globally had been steadily falling, from 239 million in 2010 to 214 million in 2015.

“Nobody should die from malaria. But the world faces a new reality: as progress stagnates, we are at risk of squandering years of toil, investment and success in reducing the number of people suffering from the disease,” says Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “We recognise we have to do something different – now. So today we are launching a country-focused and -led plan to take comprehensive action against malaria by making our work more effective where it counts most – at local level.”..

Weekly Epidemiological Record, 23 November 2018, vol. 93, 47 (pp. 633–648)
:: Progress report on the elimination of human onchocerciasis, 2017–2018
:: Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2018

WHO Regional Offices
Selected Press Releases, Announcements
WHO African Region AFRO
Selected Featured News
:: WHO calls on African countries to mobilize additional resources for the malaria response
22 November 2018
Uganda Intensifies Ebola Community Engagement to Reach Individuals, Families, the Vulnerable and Hard-to-Reach Populations  22 November 2018
Nigeria to vaccinate 26 million people in 2nd phase of biggest-ever yellow fever vaccination campaign   22 November 2018

WHO Region of the Americas PAHO
:: WHO and partners launch new country-led response to put stalled malaria control efforts back on track (11/19/2018)
:: Mobile application to facilitate introduction of a pill to prevent new cases of HIV in Latin America (11/19/2018)


WHO South-East Asia Region SEARO
:: WHO felicitates Nepal for trachoma elimination, rubella control
:: 330,000 Rohingyas and host community to get cholera vaccine in Cox’s Bazar
WHO European Region EURO
:: Early diagnosis means successful treatment: 2 men living with HIV in Greece share their experience 23-11-2018
:: Multicountry conference puts spotlight on importance of breastfeeding 22-11-2018
:: Celebrating success and inspiring progress on World Day for the Prevention of Child Abuse 19-11-2018

WHO Eastern Mediterranean Region EMRO
:: WHO ready to assist Islamic Republic of Iran to improve road safety  21 November 2018
:: WHO investigates the mass death of fish in Iraq  20 November 2018

WHO Western Pacific Region
– No new announcement identified


CDC Establishes AFM Task Force

CDC/ACIP [to 24 Nov 2018 ]

Monday, November 19, 2018
CDC Establishes AFM Task Force
CDC Director Robert R. Redfield, M.D., announced today the establishment of an Acute Flaccid Myelitis (AFM) Task Force (Task Force) to aid in the ongoing investigation to define the cause of, and improve treatment and outcomes for, patients with AFM.
The AFM Task Force will bring together experts from a variety of scientific, medical, and public health disciplines to help solve this critical public health issue.
“I want to reaffirm to parents, patients, and our Nation CDC’s commitment to this serious medical condition,” said Dr. Redfield.  “This Task Force will ensure that the full capacity of the scientific community is engaged and working together to provide important answers and solutions to actively detect, more effectively treat, and ultimately prevent AFM and its consequences.”
The Task Force will convene under CDC’s Office of Infectious Diseases’ Board of Scientific Counselors (BSC), and will make key recommendations to the BSC to inform and strengthen CDC’s response to this urgent public health concern. It will be coordinated by the Office of the Director and is scheduled to submit its first report at the BSC’s December 6, 2018, public meeting in Atlanta.
AFM is a rare condition that affects a person’s nervous system, specifically, the spinal cord, causing weakness in one or more limbs. Beginning in 2014, the United States has seen an increased number of AFM cases, mostly in children. In 2018, there have been 106 confirmed cases of AFM in 29 states; all but five have been in children ages 18 or younger.

China CDC  :: National Health Commission of the People’s Republic of China

China CDC 
New website launched…no “news” or “announcements” page identified.


National Health Commission of the People’s Republic of China
Selected Updates/ Press Releases/ Notices
2018-11-22   (chinadaily.com.cn)
Safety inspectors fail 100,000-plus doses of rabies vaccines
Drug regulators have denied market access to more than 100,000 doses of rabies vaccines produced in northeastern China in the past month, it was revealed on Nov 20.
Some 43,510 doses from Maifeng Bio Tech Co failed premarket safety and efficacy checks on Oct 29, as did 57,290 doses from Zhuoyi Biological Co on Nov 11. Both manufacturers are based in Changchun, Jilin province.
The checks were conducted by the National Institutes for Food and Drug Control, which released the information about the substandard vaccines on its website.
On Oct 23, the authority also denied market access to 77,516 doses of a rabies vaccine made by Chengda Biotech in Shenyang, Liaoning province.
China tightened supervision of vaccines this year after a scandal involving Changsheng Bio-tech Co, a major vaccine maker that was found producing substandard products…

Updated: 2018-11-22 (en.nhc.gov.cn)
NHC vice-minister attends launching ceremony of HIV testing campaign
The launching ceremony of a one-month campaign on HIV testing is held on Nov 20 in Beijing.
Wang Shenghe, vice-minister of China’s National Health Commission, addressed a launching ceremony of a month-long national HIV testing and consulting campaign on Nov 20 in Beijing.
The campaign was designed to publicize Dec 1 as World AIDS Day and to raise public awareness of HIV testing so that voluntarily testing will become more common…



BMGF – Gates Foundation  [to 24 Nov 2018 ]
No new digest content identified.
Bill & Melinda Gates Medical Research Institute    [to 24 Nov 2018 ]
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
No new digest content identified.
CARB-X   [to 24 Nov 2018 ]
CARB-X is a non-profit public-private partnership dedicated to accelerating antibacterial research to tackle the global rising threat of drug-resistant bacteria.
No new digest content identified.
CEPI – Coalition for Epidemic Preparedness Innovations  [to 24 Nov 2018 ]
No new digest content identified.
EDCTP    [to 24 Nov 2018 ]
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
No new digest content identified.
Emory Vaccine Center    [to 24 Nov 2018 ]
No new digest content identified.
European Medicines Agency  [to 24 Nov 2018 ]
News and press releases
News: Workshop on how to better support medicine developers in the generation and preparation of quality data packages for PRIME and Breakthrough Therapy applications
EMA and the US Food and Drug Administration (FDA) are organising a workshop on 26 November 2018 to discuss how regulators can better guide and support medicine developers in generating quality and manufacturing data packages in the context of development support programmes, such as the PRIority MEdicines scheme (PRIME) in the EU and Breakthrough Therapy designation programme in the US. The goal is to help patients to benefit as early as possible from these therapies that target serious or life-threatening diseases or unmet medical needs…
European Vaccine Initiative  [to 24 Nov 2018 ]
No new digest content identified.
FDA [to 24 Nov 2018 ]
No new digest content identified.
Fondation Merieux  [to 24 Nov 2018 ]
A Global Vaccinology Training Workshop to review the status of advanced vaccinology education around the world
November 22, 2018 – Les Pensières Center for Global Health, Veyrier-du-Lac (France)
The first Global Vaccinology Training Workshop was held November 7-8, 2018 at Les Pensières Center for Global Health, bringing together 42 participants from 18 countries. The workshop was organized by the Mérieux Foundation and the University of Geneva, the co-organizers of ADVAC, the Advanced Course of Vaccinology, which is given each year at Les Pensières. It convened leaders of vaccinology courses, some of which have been initiated by ADVAC alumni…
Mérieux Foundation co-organized event
10th International Global Virus Network Meeting: Eradication and Control of (Re-Emerging Viruses
November 28 – 30, 2018 – Les Pensieres Center for Global Health, Veyrier du Lac (France)

Mérieux Foundation co-organized event
OCV working group / Global Task Force on Cholera Control (GTFCC)
December 5 – 6, 2018 – Les Pensieres Center for Global Health, Veyrier-du-Lac (France)

Mérieux Foundation co-organized event
Dengue pre-vaccination screening based on serostatus: rapid tests and implementation strategies
January 14 – 16, 2019 – Les Pensières Center for Global Helath, Veyrier du Lac (France)

Gavi [to 24 Nov 2018 ]
No new digest content identified.
GHIT Fund   [to 24 Nov 2018 ]
GHIT was set up in 2012 with the aim of developing new tools to tackle infectious diseases that devastate the world’s poorest people. Other funders include six Japanese pharmaceutical
No new digest content identified.
Global Fund  [to 24 Nov 2018 ]
19 November 2018
More Efforts, Funding Needed to End Malaria
MAPUTO, Mozambique – The Global Fund joined partners at the launch of the World Malaria Report 2018 with a call to increase investments and renew efforts to accelerate progress in the fight against malaria in high burden countries.
The report by WHO shows that after more than a decade of unprecedented decline of malaria, reductions have stalled and, in some countries, the disease is on the rise…
Hilleman Laboratories   [to 24 Nov 2018 ]
No new digest content identified.
Human Vaccines Project   [to 24 Nov 2018 ]
No new digest content identified.
IAVI  [to 24 Nov 2018 ]
No new digest content identified.
No new digest content identified.
IVAC  [to 24 Nov 2018 ]
No new digest content identified.
IVI   [to 24 Nov 2018 ]
IVI News & Announcements
THSTI, IVI held joint symposium on Nov. 22
First cooperative program between International Vaccine Institute and Translational Health Science and Technology Institute expected to help accelerate cooperation between India and IVI
JEE Alliance  [to 24 Nov 2018 ]
No new digest content identified.
MSF/Médecins Sans Frontières  [to 24 Nov 2018 ]
Selected News; Project Updates, Reports
Vaccinating over 2,000 refugee children in Moria, Lesbos
Project Update 21 Nov 2018
Médecins Sans Frontières (MSF) will conduct a multi-antigen vaccination campaign for all migrant children aged under 16 on Lesbos island from 21 to 23 November, in collaboration with the Greek Ministry of Health (MoH), the Hellenic Centre for Disease Control and Prevention (HCDCP), and Médecins du Monde (MDM). MSF calls on the Greek Ministry of Health to set up routine vaccinations for all refugee children across Greece.
Due to the terrible living conditions, including the lack of basic sanitation, severe overcrowding, and extremely limited access to healthcare, coupled with the forthcoming winter, migrant children living on the Greek islands are extremely vulnerable to illness.
“The conditions in the camps are completely unacceptable and as a result, children are at a greater risk of getting seriously ill,” says Dr Declan Barry, medical coordinator for MSF in Greece. “With winter approaching, it is essential that all refugee children, who are susceptible to infections, are comprehensively vaccinated. It is every child’s right.”
DRC 2018 Ebola outbreaks
Crisis update – 19 November 2018
Treatment with developmental drugs
In our ETCs, MSF teams have been progressively increasing the level of supportive care (oral and IV hydration, treatment for malaria and other coinfections as well as treatment of the symptoms of Ebola) and have also been able to offer new potential therapeutic treatments to patients with confirmed Ebola infection under the MEURI protocol. A team of clinicians makes the choice on an ad-hoc basis between five potential drugs (Favipiravir, Remdesivir (GS5734), REGN3470-3471-3479, ZMapp, and mAb114). The treatments are given only with the informed consent of the patient (or a family member if they are too young or too sick to consent) and are provided in addition to the supportive care.
These five drugs have not passed clinical tests yet and we are unable to measure their efficacy – yet their utilization has been approved by the ethical committees of the Ministry of Health and MSF, because it is believed they may improve a patient’s chances to survive. While caution must be exercised, these treatments are an added resource to the response. Because of their untested status, their utilization is subject to a strict protocol which places particular emphasis on the informed consent of the patient. Discussions on the implementation of a proper clinical trial are ongoing.
Vaccination activities
We have vaccinated 480 frontline workers (health staff, religious leaders, burial workers, etc) from Makeke on the Ituri-North Kivu border up to Biakato, as the population from Mangina often moves in this direction. In October our teams also vaccinated 606 people, being either health workers or potential contacts of confirmed Ebola patients, in the city of Beni. In November, we have vaccinated 150 health workers in Butembo, with the plan to vaccinate 1,700 people…
NIH  [to 24 Nov 2018 ]
No new digest content identified.
PATH  [to 24 Nov 2018 ]
No new digest content identified.
Sabin Vaccine Institute  [to 24 Nov 2018 ]
No new digest content identified.
UNAIDS [to 24 Nov 2018 ]
22 November 2018
Access to quality medicines and gender-based violence discussed in Ethiopia
In order to highlight the need for sustainable and affordable access to quality medicines, the Executive Director of UNAIDS, Michel Sidibé, spoke about the necessity of implementing the African Union Pharmaceutical Manufacturing Plan. Speaking at the opening ceremony of Africa Industrialization Week 2018 in Addis Ababa, Ethiopia, he called for close cooperation with regional economic communities in order to build production cooperation hubs and lead pharmaceutical regulatory harmonization in Africa…

20 November 2018..
Yekaterinburg to be the first Russian city to sign the Paris Declaration
UNICEF  [to 24 Nov 2018 ]
Selected Press Releases/Reports/Statements
Joint statement by Mark Lowcock, Under-Secretary-General for Humanitarian Affairs and Emergency Relief Coordinator, and Henrietta Fore, UNICEF Executive Director, on the Situation in Yemen
Press release
Deep inequality continues to shape the lives of children in Iraq
First comprehensive study on the wellbeing of children in seven years
…Iraq has made notable progress on newborn and child health, including maintaining high levels of assisted births and reducing the number of children who die in their first month of life from 20 deaths per 1000 live births to 14 since the last survey was conducted in 2011. But the challenges arise soon after birth: Only 4 out of 10 of children are fully vaccinated, with the poorest children missing out the most. Half of all Iraqi households are at risk of drinking contaminated water and less than 40 per cent of the population has access to drinking water at home, placing children at grave risk of waterborne diseases…
Vaccine Confidence Project  [to 24 Nov 2018 ]
Posted on 23 Nov, 2018
Confidence Commentary:
The State of Vaccine Confidence 2018
The Lancet  COMMENT| VOLUME 392, ISSUE 10161.
[See Milestones/Perspectives above for full text]
Vaccine Education Center – Children’s Hospital of Philadelphia  [to 24 Nov 2018 ]
November 2018
Vaccine Update for Providers
Announcements: Webinar archive and 2019 dates; edit to October article, and vaccine science on Pinterest 
Wellcome Trust  [to 24 Nov 2018 ]
News | 21 November 2018
How research is helping kids growing up with congenital Zika syndrome
Three years on from an unprecedented epidemic in Central and South America, families affected by Zika are still benefiting from many research studies supported since the outbreak began.
… “What we can say at this point is that Zika virus infections in pregnancy are very serious and that the emphasis needs to be on preventing the infection from occurring,” says Brickley. “So things like vaccines and vector control are going to be pivotal in the future.”
While vector control – reducing people’s exposure to mosquitoes – is an ongoing challenge in the fight against many infections, little had been done on developing a Zika vaccine. It just hadn’t been considered a priority before.
Good progress has been made since 2015, however, and a number of candidate vaccines have entered early trials – although there is a lot of work still to be done before an effective vaccine will be available…
The Wistar Institute   [to 24 Nov 2018 ]
No new digest content identified.
World Organisation for Animal Health (OIE)   [to 24 Nov 2018 ]
Eradication isn’t the end of the Rinderpest story
OIE and FAO launch Global Action Plan to keep the world free of deadly cattle plague
…To maintain the global freedom from Rinderpest and prevent any re-introduction of the disease, the two agencies have developed a Global Action Plan published today. The plan is meant to be a guiding material for countries, outlining the responsibilities of all involved to maintain the freedom…
BIO    [to 24 Nov 2018 ]
Nov 19 2018
New Report Shows Global Link Between Pro-Innovation Policies and Biotech Advances
Washington, D.C. (November 19, 2018) – A study released today highlights strategies, policies and best practices that have been successful in creating an environment in which biotechnology innovation can flourish around the world.
The fifth edition of the Building the Bioeconomy report shows the correlation between economies with pro-innovation policy frameworks and those achieving strong biotechnology outputs. By examining 28 different indicators, the report provides a full and detailed analysis of the biotechnology environment for 33 countries from all major regions of the world…
The full report with Executive Summary is available for download at
DCVMN – Developing Country Vaccine Manufacturers Network  [to 24 Nov 2018 ]
No new digest content identified.
IFPMA   [to 24 Nov 2018 ]
No new digest content identified.
PhRMA    [to 24 Nov 2018 ]
No new digest content identified.

Journal Watch

Journal Watch

   Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focus on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.

If you would like to suggest other journal titles to include in this service, please contact David Curry at: david.r.curry@centerforvaccineethicsandpolicy.org


Cost-effectiveness of a combined intervention of long lasting insecticidal nets and indoor residual spraying compared with each intervention alone for malaria prevention in Ethiopia

BMC Cost Effectiveness and Resource Allocation
(Accessed 24 Nov 2018 )

Cost-effectiveness of a combined intervention of long lasting insecticidal nets and indoor residual spraying compared with each intervention alone for malaria prevention in Ethiopia
The effectiveness of long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), for malaria prevention, have been established in several studies. However, the available evidence about the addit…
Authors: Alemayehu Hailu, Bernt Lindtjørn, Wakgari Deressa, Taye Gari, Eskindir Loha and Bjarne Robberstad
Citation: Cost Effectiveness and Resource Allocation 2018 16:61
Published on: 22 November 2018