December 25, 2018, Vol 320, No. 24, Pages 2499-2608
The Ethics of Heritable Genome EditingNew Considerations in a Controversial Area
Eli Y. Adashi, MD, MS; I. Glenn Cohen, JD
JAMA. 2018;320(24):2531-2532. doi:10.1001/jama.2018.18270
This Viewpoint about heritable genome editing–the modification of DNA of an embryo, sperm, or egg to alter its characteristics for future generations–summarizes the 2018 Nuffield Council on Bioethics report on social and ethical issues raised by the technique, and questions its rejection of a distinction between gene editing for therapeutic vs feature enhancement purposes.