CAR T cell therapy: inroads to response and resistance

Nature Reviews Immunology
Volume 19 Issue 2, February 2019
https://www.nature.com/nri/volumes/19/issues/2

Year in Review | 10 January 2019
CAR T cell therapy: inroads to response and resistance
Several clinical studies in 2018 documented the potency of therapies based on T cells with chimeric antigen receptors (CAR T cells), but also revealed mechanisms of resistance. These insights may facilitate the design of improved CAR T cell therapies for B cell malignancies and beyond.
Christine E. Brown  & Crystal L. Mackall