Lancet Respiratory Medicine
Mar 2019 Volume 7Number 3p187-282, e10-e12
The way forward for tuberculosis vaccines
Richard G White, Willem A Hanekom, Johan Vekemans, Rebecca C Harris
Tuberculosis is now the largest single-pathogen cause of adult mortality globally; more than 10 million incident cases of the disease occur worldwide every year. In 2018, global tuberculosis prevention, diagnosis, and treatment efforts were estimated to cost US$10·4 billion. With such a high global burden, and a current average annual decline in incidence of only 1·8%, new efficacious vaccines are urgently needed to accelerate progress towards the WHO End TB and elimination goals.