A Review of Clinical Trials With an Adaptive Design and Health Economic Analysis

Value in Health
April 2019 Volume 22, Issue 4, p385-502
http://www.valueinhealthjournal.com/current

COMPARATIVE-EFFECTIVENESS RESEARCH/HTA
A Review of Clinical Trials With an Adaptive Design and Health Economic Analysis
An adaptive design uses data collected as a clinical trial progresses to inform modifications to the trial. Hence, adaptive designs and health economics aim to facilitate efficient and accurate decision making. Nevertheless, it is unclear whether the methods are considered together in the design, analysis, and reporting of trials. This review aims to establish how health economic outcomes are used in the design, analysis, and reporting of adaptive designs.
Laura Flight, Fahid Arshad, Rachel Barnsley, Kian Patel, Steven Julious, Alan Brennan, Susan Todd
p391–398
Published online: March 13, 2019