Facility-Associated Release of Polioviruses into Communities—Risks for the Posteradication Era [PDF – 2.45 MB – 7 pages]

Emerging Infectious Diseases
Volume 25, Number 7—July 2019
http://wwwnc.cdc.gov/eid/

 

Historical Review
Facility-Associated Release of Polioviruses into Communities—Risks for the Posteradication Era [PDF – 2.45 MB – 7 pages]
A. S. Bandyopadhyay et al.
Abstract
The Global Polio Eradication Initiative continues to make progress toward the eradication target. Indigenous wild poliovirus (WPV) type 2 was last detected in 1999, WPV type 3 was last detected in 2012, and over the past 2 years WPV type 1 has been detected only in parts of 2 countries (Afghanistan and Pakistan). Once the eradication of poliomyelitis is achieved, infectious and potentially infectious poliovirus materials retained in laboratories, vaccine production sites, and other storage facilities will continue to pose a risk for poliovirus reintroduction into communities. The recent breach in containment of WPV type 2 in an inactivated poliovirus vaccine manufacturing site in the Netherlands prompted this review, which summarizes information on facility-associated release of polioviruses into communities reported over >8 decades. Successful polio eradication requires the management of poliovirus containment posteradication to prevent the consequences of the reestablishment of poliovirus transmission.