Emergencies

Emergencies

POLIO
Public Health Emergency of International Concern (PHEIC)
Polio this week as of 10 July 2019
:: A circulating vaccine-derived poliovirus type 2 (cVDPV2) has been confirmed in China. It is genetically linked to a VDPV2 isolated from an environmental sample from Xinjiang province, collected on 18 April 2018.  WHO is continuing to evaluate the situation and stands ready to support the ongoing investigation and risk assessment by national authorities.

Summary of new viruses this week:
:: Pakistan — nine wild poliovirus type 1 (WPV1) cases and 3 WPV1-positive environmental samples;
:: Angola —  one circulating vaccine-derived poliovirus  (cVDPV2) case;
:: China – one cVDPV2 case. See country sections below for more details.

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Editor’s Note:
WHO has posted a refreshed emergencies page which presents an updated listing of Grade 3,2,1 emergencies as below.
WHO Grade 3 Emergencies [to 13 Jul 2019]

Democratic Republic of the Congo
:: 49: Situation report on the Ebola outbreak in North Kivu 9 July 2019
:: Disease Outbreak News (DONs} Ebola virus disease – Democratic Republic of the Congo
11 July 2019
[See DRC Ebola+ above for detail]

Yemen
:: Outbreak update – Cholera in Yemen, 30 June 2019
8 July 2019 – The Ministry of Public Health and Population of Yemen reported 21,865 suspected cases of cholera with 13 associated deaths during epidemiological week 26 (24 to 30 June) of 2019. Thirteen percent of cases were severe. The cumulative total number of suspected cholera cases from 1 January 2018 to 30 June 2019 is 823,221, with 1210 associated deaths (CFR 0.13%). Children under five represent 23.0% of total suspected cases during 2019. The outbreak has affected 22 of 23 governorates and 299 of 333 districts in Yemen…

Nigeria
:: Nigeria intensifies cross border immunization, with special focus on nomadic populations 
Kano, 8 July, 2019 – In renewed efforts to vaccinate children traversing in and out of Nigeria, the World Health Organization (WHO) is supporting the government in an initiative to improve supplemental and routine immunization activities in the North Western region, which has a significant nomadic population.
Nomadic pastoralists live beyond the reach of established health care programs that are designed to serve sedentary populations. As a result, these groups are often under-immunized and out of the reach of existing disease surveillance activities.
Speaking on the intervention, Mallam Gwanda Mairakuma of Maiadua local government in Niger Republic said that, “with this intensified commitment, vaccination activities have reduced the number of complications associated with Measles infection on our children”…

Mozambique floods – No new digest announcements identified
Myanmar – No new digest announcements identified
Somalia – No new digest announcements identified
South Sudan – No new digest announcements identified
Syrian Arab Republic – No new digest announcements identified

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WHO Grade 2 Emergencies [to 13 Jul 2019]

Libya
:: Medical aid accelerated as Libya crisis intensifies 6 July 2019

MERS-CoV
:: Worldwide reduction in MERS cases and deaths since 2016 8 July 2019
The World Health Organization and colleagues from the University of Oxford, Imperial College London and Institut Pasteur* have estimated that, since 2016, 1 465 cases of Middle East Respiratory syndrome coronavirus (MERS-CoV) and between 300 and 500 deaths may have been averted due to accelerated global efforts to detect infections early and reduce transmission.
In 2012, a novel virus that had not previously been seen in humans was identified for the first time in a resident from Saudi Arabia. The virus, now known as MERS-CoV, has, as of 31 May 2019, infected more than 2 442 people worldwide. MERS-CoV is a respiratory virus that can cause severe disease and has been fatal in approximately 35% of patients to date. MERS is zoonotic and people are infected from direct or indirect contact with dromedary camels. While the virus has demonstrated limited ability to transmit between people outside of hospitals, it has repeatedly caused large scale outbreaks in health care facilities with severe health, security and economic impacts, most notably in Saudi Arabia in 2014-2016 and the Republic of Korea in 2015. The outbreak in the Republic of Korea in 2015 involved 186 cases and 38 deaths, and had an estimated economic impact of US$12 billion.
In a research letter published in the journal Emerging Infectious Diseases on 8 July 2019, the researchers analyze case-based data on laboratory-confirmed MERS-CoV infections reported to WHO since 2012…

Afghanistan – No new digest announcements identified
Bangladesh – Rakhine conflict – No new digest announcements identified
Cameroon – No new digest announcements identified
Central African Republic – No new digest announcements identified
Cyclone Idai – No new digest announcements identified
Ethiopia – No new digest announcements identified
Iran floods 2019 – No new digest announcements identified
Iraq – No new digest announcements identified
Malawi floods – No new digest announcements identified
Niger – No new digest announcements identified
occupied Palestinian territory – No new digest announcements identified
Sudan – No new digest announcements identified
Ukraine – No new digest announcements identified
Zimbabwe – No new digest announcements identified

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WHO Grade 1 Emergencies [to 13 Jul 2019]

Angola – No new digest announcements identified
Chad – No new digest announcements identified
Djibouti – No new digest announcements identified
Indonesia – Sulawesi earthquake 2018 – No new digest announcements identified
Kenya – No new digest announcements identified
Mali – No new digest announcements identified
Namibia – viral hepatitis – No new digest announcements identified
Tanzania – No new digest announcements identified

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UN OCHA – L3 Emergencies
The UN and its humanitarian partners are currently responding to three ‘L3’ emergencies. This is the global humanitarian system’s classification for the response to the most severe, large-scale humanitarian crises. 
Syrian Arab Republic
:: Syrian Arab Republic: Recent Developments in Northwestern Syria Situation Report No. 7 – as of 12 July 2019
HIGHLIGHTS
:: …Humanitarian response is ongoing with hundreds of thousands of people receiving critical assistance essential for their survival. Violence in areas directly affected by conflict is driving displacement into denselypopulated areas, putting a strain on service delivery for humanitarian actors. A joint assessment is currently being finalized that will provide an overview of needs in the most affected areas.
:: Civilian infrastructure, including humanitarian facilities, continues to be damaged or destroyed in the violence. In the last two weeks, at least four medical facilities have been impacted by the violence, with several other unconfirmed reports, as well as a water station serving over 80,000 people, and several schools, IDP settlements, markets and bakeries.

Yemen – No new digest announcements identified

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UN OCHA – Corporate Emergencies
When the USG/ERC declares a Corporate Emergency Response, all OCHA offices, branches and sections provide their full support to response activities both at HQ and in the field.
Editor’s Note:
Ebola in the DRC has bene added as a OCHA “Corporate Emergency” this week:
CYCLONE IDAI and Kenneth
:: Southern Africa: Cyclones Idai and Kenneth Snapshot, as of 10 July 2019.

EBOLA OUTBREAK IN THE DRC – No new digest announcements identified

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WHO & Regional Offices [to 13 Jul 2019]

WHO & Regional Offices [to 13 Jul 2019]
WHO updates global guidance on medicines and diagnostic tests to address health challenges, prioritize highly effective therapeutics, and improve affordable access
New essential medicines and diagnostics lists published today
9 July 2019 News release Geneva
[See Milestones above for detail]

 

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Calls for consultants / proposals
8 July 2019
Consultancy – Support for WHO’s work on advancing vaccine development and vaccination against yellow fever, Zika, and dengue
Deadline for applications: 25 July 2019

 

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Weekly Epidemiological Record, 12 July 2019, vol. 94, 28 (pp. 309–316)
:: Global Advisory Committee on Vaccine Safety, 5–6 June 2019

 

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WHO Regional Offices
Selected Press Releases, Announcements
WHO African Region AFRO
:: Marginalised and mistrustful: listening to people who have few reasons to trust outsiders [DRC] 13 July 2019
:: Uganda Village joins forces to Fight Ebola 11 July 2019

WHO Region of the Americas PAHO
:: PAHO/WHO urges northern hemisphere countries to prepare for heatwaves  (07/12/2019)
:: CDB, PAHO launch “Stronger Together” campaign, raising awareness about mental health and psychosocial support in disasters (07/10/2019)

WHO South-East Asia Region SEARO
:: Sri Lanka eliminates measles SEAR/PR/1712
New Delhi, 9 July 2019: The World Health Organization today announced Sri Lanka has eliminated measles, interrupting transmission of the indigenous virus that causes the killer childhood disease.
“Sri Lanka’s achievement comes at a time when globally measles cases are increasing. The country’s success demonstrates its commitment, and the determination of its health workforce and parents to protect children against measles,” said Dr Poonam Khetrapal Singh, Regional Director WHO South-East Asia, congratulating the island nation…

WHO European Region EURO
– No new digest announcements identified

WHO Eastern Mediterranean Region EMRO
– No new digest announcements identified

WHO Western Pacific Region
– No new digest announcements identified

CDC/ACIP [to 13 Jul 2019]

CDC/ACIP [to 13 Jul 2019]
http://www.cdc.gov/media/index.html
https://www.cdc.gov/vaccines/acip/index.html
Thursday, July 11, 2019
TRANSCRIPT of July 9, 2019, CDC Vital Signs: Nationwide Outbreak of Acute Flaccid Myelitis—United States, 2018

CDC Lab Research Shows Two Treatments Effective Against DRC Ebola Strain
Tuesday, July 9, 2019
[See DRC – Ebola above for detail]

CDC Telebriefing-New Vital Signs Report – CDC reports on largest acute flaccid myelitis (AFM) outbreak: doctors should recognize symptoms early and report all suspected cases
Tuesday, July 9, 2019

CDC Urges Doctors to Rapidly Recognize and Report AFM Cases
Tuesday, July 9, 2019

MMWR News Synopsis for July 12, 2019
Changes in HIV Preexposure Prophylaxis (PrEP) Awareness and Use Among Men Who Have Sex with Men — 20 Urban Areas, 2014 and 2017
Use of a daily pill for HIV prevention – HIV preexposure prophylaxis or PrEP – has increased but remains too low, particularly among gay and bisexual African American and Latino men. More gay and bisexual men at high risk for HIV are using PrEP. CDC analyzed data from more than 7,800 interviews with gay and bisexual men at high risk for HIV in 20 U.S. cities. The analysis found that reported PrEP use increased from 6% to 35% — and that reported awareness of PrEP increased from 60% to 90% — among the survey participants between 2014 and 2019. Despite those increases, PrEP use remains too low. African American and Latino gay and bisexual men reported lower PrEP awareness and use than white gay and bisexual men. To end the HIV epidemic in the United States, healthcare providers should routinely test their patients for HIV, assess HIV-negative patients for indications of HIV risk, and appropriately prescribe PrEP.

Vital Signs: Surveillance for Acute Flaccid Myelitis — United States, 2018

Africa CDC [to 13 Jul 2019]

Africa CDC [to 13 Jul 2019]
http://www.africacdc.org/
27-06-2019
AUC and Government of China Sign Exchange of Letters of Agreement for the Construction of Africa CDC Headquarters Building
…The signing of the Exchange of Letters of Agreement is an important step towards actualization of the construction project. It paves the way for the signing of an Agreement on the Economic and Technical Cooperation for the provision of the grant aid for the construction, commencement of the project design, and subsequent laying of the foundation.

China CDC

China CDC
http://www.chinacdc.cn/en/
No new digest content identified.

 

National Health Commission of the People’s Republic of China
http://en.nhc.gov.cn/
2019-07-12
All children with leukemia included in national centralized treatment and management system
China’s program of leukemia centralized treatment and management has covered all children in the country, and already benefited 35,000 kids, according to the National Health Commission.

Chinese hospital publishes brain tumor database
2019-07-10
China’s leading neurosurgery hospital has published a database of 2,000 gene samples from Chinese patients with glioma, a type of brain tumor.

All poor rural areas to get basic healthcare access
2019-07-10
All residents in impoverished rural areas are expected to have access to basic healthcare services provided by certified doctors by the end of the year.

Announcements

Announcements

Paul G. Allen Frontiers Group [to 13 Jul 2019]
https://alleninstitute.org/what-we-do/frontiers-group/news-press/
Press Release
Advancing Leading Edge Cancer Research in a $4.5 Million Collaboration
July 11, 2019
LLS, The Mark Foundation for Cancer Research and The Paul G. Allen Frontiers Group Join Forces to Advance Leading Edge Cancer Research

BMGF – Gates Foundation [to 13 Jul 2019]
http://www.gatesfoundation.org/Media-Center/Press-Releases
No new digest content identified.

Bill & Melinda Gates Medical Research Institute [to 13 Jul 2019]
https://www.gatesmri.org/
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
No new digest content identified.

CARB-X [to 13 Jul 2019]
https://carb-x.org/
CARB-X is a non-profit public-private partnership dedicated to accelerating antibacterial research to tackle the global rising threat of drug-resistant bacteria.
No new digest content identified.

CEPI – Coalition for Epidemic Preparedness Innovations [to 13 Jul 2019]
http://cepi.net/
10 July 2019
CEPI awards contract worth up to US$12.5 million to consortium led by Wageningen Bioveterinary Research to develop a human vaccine against Rift Valley fever
With support from the EU’s Horizon 2020 programme, CEPI will provide funding for vaccine manufacturing, preclinical research, and a phase 1 study to assess a single-dose vaccine candidate.

Clinton Health Access Initiative, Inc. (CHAI) [to 13 Jul 2019]
https://clintonhealthaccess.org/about/
No new digest content identified.

EDCTP [to 13 Jul 2019]
http://www.edctp.org/
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
Latest news
12 July 2019
Director General Jean-Eric Paquet visits EDCTP-funded CHAPS adolescent study in Cape Town
On 8 July 2019, the European Commission Director-General for Research and Innovation, Jean-Eric Paquet, visited the Emavulandleni Research Centre in Cape Town, South Africa, together with colleagues from the European Commission, the Department of Science and Technology of South Africa, the South African Medical Research Council and EDCTP. This research centre is one of the sites for the EDCTP-funded ‘Combined HIV Adolescent Prevention Study’ (CHAPS), led by Professor Linda Gail-Bekker and conducted South Africa, Uganda and Zimbabwe.

Emory Vaccine Center [to 13 Jul 2019]
http://www.vaccines.emory.edu/
No new digest content identified.

European Medicines Agency [to 13 Jul 2019]
http://www.ema.europa.eu/ema/
News and press releases
Press release: EU and US reach a milestone in mutual recognition of inspections of medicines manufacturers
Last updated: 12/07/2019

Press release: Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 8-11 July 2019
PRAC, Last updated: 11/07/2019

News: Guido Rasi elected chair of International Coalition of Medicines Regulatory Authorities (ICMRA)
Last updated: 08/07/2019

European Vaccine Initiative [to 13 Jul 2019]
http://www.euvaccine.eu/news-events
No new digest content identified.

FDA [to 13 Jul 2019]
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/default.htm
No new digest content identified.

Fondation Merieux [to 13 Jul 2019]
http://www.fondation-merieux.org/
No new digest content identified.

Gavi [to 13 Jul 2019]
https://www.gavi.org/
No new digest content identified.

GHIT Fund [to 13 Jul 2019]
https://www.ghitfund.org/newsroom/press
GHIT was set up in 2012 with the aim of developing new tools to tackle infectious diseases that devastate the world’s poorest people. Other funders include six Japanese pharmaceutical
No new digest content identified.

Global Fund [to 13 Jul 2019]
https://www.theglobalfund.org/en/news/
No new digest content identified.

Hilleman Laboratories [to 13 Jul 2019]
http://www.hillemanlabs.org/
No new digest content identified.

Human Vaccines Project [to 13 Jul 2019]
http://www.humanvaccinesproject.org/media/press-releases/
No new digest content identified.

IAVI [to 13 Jul 2019]
https://www.iavi.org/newsroom
No new digest content identified.

International Coalition of Medicines Regulatory Authorities (ICMRA)
http://www.icmra.info/drupal/en/news
Monday 8 July 2019
Election of New Chair and Vice Chairs of ICMRA (July 2019)
…ICMRA brings together the leaders of regulatory authorities around the world to provide
strategic direction for enhanced cooperation on common scientific, regulatory or safety
challenges, improved communication and information sharing and effective global crisis
response mechanisms…

IFFIm
http://www.iffim.org/library/news/press-releases/
No new digest content identified.

IFRC [to 13 Jul 2019]
http://media.ifrc.org/ifrc/news/press-releases/
Selected Press Releases, Announcements
Asia Pacific, Bangladesh
Cox’s Bazar: Heavy rains trigger landslides in camps, Red Crescent response efforts underway
Cox’s Bazar/Kuala Lumpur/Geneva, 11 July 2019 – Heavy rains triggered landslides in camps in Cox’s Bazar housing more than 900,000 people from Rakhine state, Myanmar. Bangladesh Red Crescent Society response operations are underway in seven camps where …
11 July 2019

IVAC [to 13 Jul 2019]
https://www.jhsph.edu/research/centers-and-institutes/ivac/index.html
No new digest content identified.

IVI [to 13 Jul 2019]
http://www.ivi.int/
IVI News & Announcements
IVI exchanged a memorandum of understanding with the Armed Forces Medical Research Institute (AFMRI)
July 12, 2019 – SEOUL, South Korea. Today IVI exchanged a memorandum of understanding with the Armed Forces Medical Research Institute (AFMRI), the Korean military’s only institution dedicated to medical research and development, prevention of diseases, and promotion of health of military personnel.
Through this partnership, IVI and AFMRI will seek the exchange of research resources and close cooperation for the development of a vaccine against human adenovirus type 55, which is reported to cause outbreaks of acute respiratory diseases among military trainees and in school populations around the world. Both parties will also aim to facilitate discussions to explore and conduct joint research projects, and to support the vaccination of the Armed Forces…

JEE Alliance [to 13 Jul 2019]
https://www.jeealliance.org/
Selected News and Events
No new digest content identified.

MSF/Médecins Sans Frontières [to 13 Jul 2019]
http://www.msf.org/
Selected News; Project Updates, Reports
Ethiopia
The constant cycle of displacement
Project Update 12 Jul 2019

Iraq
Supporting people in Qayyarah
Project Update 12 Jul 2019

Democratic Republic of Congo
Six years on, still no news of our colleagues held hostage by armed group…
Statement 11 Jul 2019

Annual Report
International Activity Report 2018
10 Jul 2019

Pakistan
The only option for cutaneous leishmaniasis treatment in Khyber Pa…
Project Update 9 Jul 2019

Myanmar
Clinic closure marks milestone for HIV treatment in Myanmar
Project Update 8 Jul 2019

NIH [to 13 Jul 2019]
http://www.nih.gov/news-events/news-releases
Friday, July 5, 2019
Novel Method Identifies Patients at Risk for HIV Who May Benefit From Prevention Strategies
NIH-funded studies demonstrate the value of automated prediction algorithms that could be used to prevent new HIV infections

PATH [to 13 Jul 2019]
https://www.path.org/media-center/
July 9, 2019 by PATH
PATH applauds recognition for frontline treatment of childhood diarrheal disease by the World Health Organization
New listing for co-packaged ORS-zinc in the WHO essential medicines list could improve access and save lives
Seattle, Washington, USA, July 9, 2019 – PATH applauds a landmark decision this week by the World Health Organization (WHO) to include a new listing for co-packaged oral rehydration salts (ORS) and zinc sulfate in its Model List of Essential Medicines (EML) and Model List of Essential Medicines for Children (EMLc), reinforcing the lifesaving benefits of using ORS and zinc together for pediatric diarrhea management, and achieving alignment with the long-standing recommendation for the use of both therapies as frontline practice. It is estimated that more than 60 percent of childhood diarrheal deaths could be prevented with full coverage of ORS and zinc alongside other community interventions…

Sabin Vaccine Institute [to 13 Jul 2019]
http://www.sabin.org/updates/pressreleases
No new digest content identified.

UNAIDS [to 13 Jul 2019]
http://www.unaids.org/en
Selected Press Releases/Reports/Statements
12 July 2019
Charting progress against discrimination
Laws discriminate in many ways, but the criminalization of people is one of the most devastating forms of discrimination. Despite calls for reform and the commitments under the 2030 Agenda for Sustainable Development to remove discriminatory laws and reduce inequalities:

:: Sixty-nine countries still criminalize same-sex sexual relationships.
:: More than 100 countries criminalize drug use or the personal possession of drugs and 98 countries criminalize some form of sex work.
:: One in five people in prison are there because of drug-related crimes and 80% of those are there for personal possession or use.
:: Nineteen countries deport non-nationals on the grounds of their HIV status.

A high-level political forum is meeting in New York, United States of America, from 9 to 18 July to review the progress made against the commitments of Member States towards achieving the Sustainable Development Goals, including those on inequality and on peace, justice and strong institutions…

10 July 2019
Youth networks are saving lives
A study undertaken by Watipa and commissioned by UNAIDS and the PACT as part of its #uproot agenda found that young people play an essential role in demand creation, linkages to care and uptake of services for HIV and sexual and reproductive health and rights.
The report showcasing the results, titled Young people’s participation in community-based responses to HIV: from passive beneficiaries to active agents of change, showed that young people, particularly role models and leaders who are living with HIV, play a critical part in enabling access to HIV treatment and retention in care. The results showed that the support provided by young people to their peers has a positive effect on antiretroviral therapy adherence, navigating disclosure and living positively with HIV. Details of the types of support show that young people are actively involved in peer psychosocial support, peer-to-peer consultations, policy engagement processes, peer mobilization around specific campaigns and projects, and peer-supported hospital and care access…

UNICEF [to 13 Jul 2019]
https://www.unicef.org/media/press-releases
Selected Statements, Press Releases, Reports
Statement
Attack in Afrin, Syria, kills three children and causes significant damage to school
Statement from Geert Cappelaere, UNICEF Regional Director for the Middle East and North Africa
12/07/2019

Press release
Vaccination to contain severe measles outbreak underway in the Democratic Republic of the Congo amidst Ebola and mass displacement
Campaign led by the Ministry of Health with support from UNICEF and MSF
11/07/2019
[See Milestones above for detail]

Press release
Rohingya refugee children in Cox’s Bazar at risk from flooding and landslides as monsoon rains continue
Education for over 60,000 children in camps and host community is disrupted because of damage to learning centres
09/07/2019

Statement
At least seven children killed in yet another attack on civilians in northwest Syria
Statement by UNICEF Executive Director Henrietta Fore

Vaccine Confidence Project [to 13 Jul 2019]
http://www.vaccineconfidence.org/
No new digest content identified.

Vaccine Education Center – Children’s Hospital of Philadelphia [to 13 Jul 2019]
http://www.chop.edu/centers-programs/vaccine-education-center
No new digest content identified.

Wellcome Trust [to 13 Jul 2019]
https://wellcome.ac.uk/news
Opinion | 11 July 2019
Public health funding: a new approach to address conditions like obesity and cancer
by Sophie Hawkesworth, Portfolio Manager Population Health, Wellcome

The Wistar Institute [to 13 Jul 2019]
https://www.wistar.org/news/press-releases
Press Release
Jul. 9, 2019
Consortium of HIV Researchers Puts Philadelphia at Global Center of Research Advances Toward a Cure for HIV/AIDS
Wistar and partners unveil educational videos focused on taking part in a cure-directed clinical trial.

World Organisation for Animal Health (OIE) [to 13 Jul 2019]
http://www.oie.int/en/for-the-media/press-releases/2019/
No new digest content identified.

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BIO [to 13 Jul 2019]
https://www.bio.org/insights/press-release
No new digest content identified.

DCVMN – Developing Country Vaccine Manufacturers Network [to 13 Jul 2019]
http://www.dcvmn.org/
No new digest content ide
ntified.

IFPMA [to 13 Jul 2019]
http://www.ifpma.org/resources/news-releases/
No new digest content identified.

PhRMA [to 13 Jul 2019]
http://www.phrma.org/press-room
No new digest content identified.

Journal Watch

Journal Watch
Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focu-s on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.
If you would like to suggest other journal titles to include in this service, please contact David Curry at: david.r.curry@centerforvaccineethicsandpolicy.org

Emerging Trends in Clinical Tropical Medicine Research

American Journal of Tropical Medicine and Hygiene
Volume 101, Issue 1, 2019
http://www.ajtmh.org/content/journals/14761645/101/1

 

Perspective Piece
Emerging Trends in Clinical Tropical Medicine Research
Mark K. Huntington, Joe P. Bryan, Troy D. Moon, Pascal J. Imperato, Susan L. F. McLellan, Walter R. Taylor and John S. Schieffelin
https://doi.org/10.4269/ajtmh.19-0043
The American Society for Tropical Medicine and Hygiene recently inaugurated an award for the best clinical research article published in the society’s journal in the previous year. This article summarizes both the process of selecting the winner and several themes that stood out in those articles which rose to the top for consideration. Themes of note included the importance of doing clinical research outside of referral centers, the complexity that must be considered when implementing interventions, incorporation of both ends of the age spectrum into studies, and considering cost-effectiveness and opportunity cost of interventions.

High Rates of Exposures to Waterborne Pathogens in Indigenous Communities in the Amazon Region of Ecuador

American Journal of Tropical Medicine and Hygiene
Volume 101, Issue 1, 2019
http://www.ajtmh.org/content/journals/14761645/101/1

 

Articles
High Rates of Exposures to Waterborne Pathogens in Indigenous Communities in the Amazon Region of Ecuador
Natalia Romero-Sandoval, Lizeth Cifuentes, Gabriela León, Paola Lecaro, Claudia Ortiz-Rico, Philip Cooper and Miguel Martín
https://doi.org/10.4269/ajtmh.18-0970
Waterborne pathogens, associated with poverty and poor sanitary conditions, are a major cause of morbidity and mortality worldwide. There are limited data on the epidemiology of waterborne pathogens in indigenous populations living in the Amazon region. We did a cross-sectional survey in two indigenous Shuar communities in the Amazon region of Ecuador in which we documented the presence of pathogens representing different sources of environmental contamination of water. We detected protozoa and soil-transmitted helminths by microscopy of fecal samples and the presence of IgG antibodies to hepatitis A and Leptospira spp. in blood samples from individuals older than 2 years and collected data by questionnaire on sociodemographic factors and knowledge of infectious diseases. Seroprevalence for hepatitis A and Leptospira spp. were 98.1% (95% CI: 97.0–99.8) and 50.0% (95% CI: 43.3–56.6), respectively, whereas 62.6% (95% CI: 55.8–69.4) had enteric parasites in stool samples. In participants older than 6 years, eight of 10 had evidence of infection with or exposure to at least one of the pathogens studied. Although prevalence of pathogens varied by age, it did not vary significantly by gender, temporal migration, illiteracy, perceived morbidity, receipt of conditional cash transfers, water boiling practices, poor housing conditions, and anthropometric status. These findings indicate a high level of contamination of drinking water by human pathogens in these indigenous communities and the need for interventions to improve access to and use of clean drinking water in these marginalized communities.

Impact of a guideline-based best practice alert on pneumococcal vaccination rates in adults in a primary care setting

BMC Health Services Research
http://www.biomedcentral.com/bmchealthservres/content
(Accessed 13 Jul 2019)

 

Research article
Impact of a guideline-based best practice alert on pneumococcal vaccination rates in adults in a primary care setting [U.S.]
Despite the high burden of pneumococcal disease, pneumococcal vaccine coverage continues to fall short of Healthy People 2020 goals. A quasi-experimental design was used to investigate the impact of pneumococc…
Authors: Carrie McAdam-Marx, Casey Tak, Tanaz Petigara, Nathan W. Jones, Minkyoung Yoo, Melissa Struwe Briley, Karen Gunning and Lisa Gren
Citation: BMC Health Services Research 2019 19:474
Published on: 10 July 2019

Implementation of the World’s largest measles-rubella mass vaccination campaign in Bangladesh: a process evaluation

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 13 Jul 2019)

 

Research article
Implementation of the World’s largest measles-rubella mass vaccination campaign in Bangladesh: a process evaluation
Gavi, the Vaccine Alliance, supported a mass vaccination Measles-Rubella Campaign (MRC) in Bangladesh during January–February 2014.
Authors: Haribondhu Sarma, Ashwin Budden, Sharmin Khan Luies, Stephen S. Lim, Md. Shamsuzzaman, Tahmina Sultana, Julie K. Rajaratnam, Laura Craw, Cathy Banwell, Md. Wazed Ali and Md. Jasim Uddin
Citation: BMC Public Health 2019 19:925
Published on: 10 July 2019

Trajectories of seasonal influenza vaccine uptake among French people with diabetes: a nationwide retrospective cohort study, 2006–2015

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 13 Jul 2019)

 

Research article
Trajectories of seasonal influenza vaccine uptake among French people with diabetes: a nationwide retrospective cohort study, 2006–2015
Annual seasonal influenza vaccination (SIV) is recommended for people with diabetes, but their SIV rates remain far below public health targets. We aimed to identify temporal trajectories of SIV uptake over a …
Authors: Aurélie Bocquier, Sébastien Cortaredona, Lisa Fressard, Pierre Loulergue, Jocelyn Raude, Ariane Sultan, Florence Galtier and Pierre Verger
Citation: BMC Public Health 2019 19:918
Published on: 9 July 2019

Twenty Years Of Antiretroviral Therapy For People Living With HIV: Global Costs, Health Achievements, Economic Benefits

Health Affairs
Vol. 38, No. 7 July 2019
https://www.healthaffairs.org/toc/hlthaff/current

 

Physicians, Nurses, Disparities & More
Research Article Global Health Policy
Twenty Years Of Antiretroviral Therapy For People Living With HIV: Global Costs, Health Achievements, Economic Benefits
Steven S. Forsythe , William McGreevey , Alan Whiteside , Maunank Shah ,

Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation – A Randomized Clinical Trial

JAMA
July 9, 2019, Vol 322, No. 2, Pages 95-180
http://jama.jamanetwork.com/issue.aspx

 

Original Investigation
Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation – A Randomized Clinical Trial
Adriana Bastidas, MD; Javier de la Serna, MD; Mohamed El Idrissi, MSc; et al.
JAMA. 2019;322(2):123-133. doi:10.1001/jama.2019.9053
This randomized trial compares the effects of 2 doses of nonlive adjuvanted recombinant zoster vaccine vs placebo on incidence of herpes zoster in adults who had undergone autologous hematopoietic stem cell transplantation.

Trust Between Health Care and Community Organizations

JAMA
July 9, 2019, Vol 322, No. 2, Pages 95-180
http://jama.jamanetwork.com/issue.aspx

 

Viewpoint
Trust in Health Care
Trust Between Health Care and Community Organizations
Somava Saha Stout, MD, MS; Lisa A. Simpson, MB, BCh, MPH; Prabhjot Singh, MD, PhD
JAMA. 2019;322(2):109-110. doi:10.1001/jama.2019.1211
This Viewpoint discusses the importance of trust in partnerships between health care and community-based organizations for achieving better health outcomes and proposes principles and strategies for building and nurturing trustworthy collaborations.

Building Trust in Health Systems to Eliminate Health Disparities

JAMA
July 9, 2019, Vol 322, No. 2, Pages 95-180
http://jama.jamanetwork.com/issue.aspx

 

Trust in Health Care
Building Trust in Health Systems to Eliminate Health Disparities
Donald E. Wesson, MD, MBA; Catherine R. Lucey, MD; Lisa A. Cooper, MD, MPH
JAMA. 2019;322(2):111-112. doi:10.1001/jama.2019.1924
This Viewpoint discusses the historic lack of trust between health systems and underserved communities and suggests evidence-based strategies to build the trusting relationships needed to address this complex social problem.

Ebola vaccines: ready to use for humanitarian health workers?

Journal of Travel Medicine
Volume 26, Issue 5, 2019,
https://academic.oup.com/jtm/issue/26/5

 

Perspectives
Ebola vaccines: ready to use for humanitarian health workers?
Blaise Genton, MD, PhD
Journal of Travel Medicine, Volume 26, Issue 5, 2019, tay152, https://doi.org/10.1093/jtm/tay152
Humanitarian health workers are likely to benefit from immunization with an Ebola vaccine when deployed in epidemic zones. However implementation is difficult since there is yet not licensed vaccine that can be administered before they reach the field. Also several uncertainties remain (safety, cross-protection between species, duration of protection etc.).

Japanese encephalitis vaccine for travelers: risk-benefit reconsidered

Journal of Travel Medicine
Volume 26, Issue 5, 2019,
https://academic.oup.com/jtm/issue/26/5

 

Editor’s Choice
Japanese encephalitis vaccine for travelers: risk-benefit reconsidered
Bradley A Connor, MD; Davidson H Hamer, MD; Phyllis Kozarsky, MD; Elaine Jong, MD; Scott B Halstead, MD
Journal of Travel Medicine, Volume 26, Issue 5, 2019, taz037, https://doi.org/10.1093/jtm/taz037

Japanese encephalitis vaccine for travelers: risk-benefit reconsidered

Journal of Travel Medicine
Volume 26, Issue 5, 2019,
https://academic.oup.com/jtm/issue/26/5

 

Editor’s Choice
Japanese encephalitis vaccine for travelers: risk-benefit reconsidered
Bradley A Connor, MD; Davidson H Hamer, MD; Phyllis Kozarsky, MD; Elaine Jong, MD; Scott B Halstead, MD
Journal of Travel Medicine, Volume 26, Issue 5, 2019, taz037, https://doi.org/10.1093/jtm/taz037

Meningitis vaccine shortage and the 2019 Hajj mass gathering: market dynamics and epidemic control

Journal of Travel Medicine
Volume 26, Issue 5, 2019,
https://academic.oup.com/jtm/issue/26/5

 

Rapid Communication
Meningitis vaccine shortage and the 2019 Hajj mass gathering: market dynamics and epidemic control
Shahul H Ebrahim, MD, MSc, PhD; Abdullah M Assiri, MD, FACP; Ziad A Memish, MD, FRCPC, FRCPL, FRCPE, FACP, FFPH
Journal of Travel Medicine, Volume 26, Issue 5, 2019, taz039, https://doi.org/10.1093/jtm/taz039
Extract
Saudi Arabia implements two meningococcal meningitis epidemic control strategies for Hajj pilgrims. Visa-linked meningococcal vaccination certification (A, C, Y, W-135) is mandatory for all pilgrims. In addition, for those arriving from the `meningitis belt countries’, a single dose of oral ciprofloxacin is administered at arrival ports prior to the immigration process to eliminate meningococcal nasopharyngeal carriage (1). Hajj and Umrah constitute the largest annual mass gathering of pilgrims from over 180 countries with a projected growth from current 3 million to 30 million by 2030 (2). With these dual approaches, meningococcal carriage rates have been…

Meningitis vaccine shortage and the 2019 Hajj mass gathering: market dynamics and epidemic control

Journal of Travel Medicine
Volume 26, Issue 5, 2019,
https://academic.oup.com/jtm/issue/26/5

 

Rapid Communication
Meningitis vaccine shortage and the 2019 Hajj mass gathering: market dynamics and epidemic control
Shahul H Ebrahim, MD, MSc, PhD; Abdullah M Assiri, MD, FACP; Ziad A Memish, MD, FRCPC, FRCPL, FRCPE, FACP, FFPH
Journal of Travel Medicine, Volume 26, Issue 5, 2019, taz039, https://doi.org/10.1093/jtm/taz039
Extract
Saudi Arabia implements two meningococcal meningitis epidemic control strategies for Hajj pilgrims. Visa-linked meningococcal vaccination certification (A, C, Y, W-135) is mandatory for all pilgrims. In addition, for those arriving from the `meningitis belt countries’, a single dose of oral ciprofloxacin is administered at arrival ports prior to the immigration process to eliminate meningococcal nasopharyngeal carriage (1). Hajj and Umrah constitute the largest annual mass gathering of pilgrims from over 180 countries with a projected growth from current 3 million to 30 million by 2030 (2). With these dual approaches, meningococcal carriage rates have been…

The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study

The Lancet
Jul 13, 2019 Volume 394Number 10193p93-186
https://www.thelancet.com/journals/lancet/issue/current

 

Articles
The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study
We found that the novel OPV2 candidates were safe and immunogenic in IPV-immunised adults, and our data support the further development of these vaccines to potentially be used for maintaining global eradication of neurovirulent type-2 polioviruses.
Pierre Van Damme, et al
Open Access

The G20 and development assistance for health: historical trends and crucial questions to inform a new era

The Lancet
Jul 13, 2019 Volume 394Number 10193p93-186
https://www.thelancet.com/journals/lancet/issue/current

 

Health Policy
The G20 and development assistance for health: historical trends and crucial questions to inform a new era
Joseph L Dieleman, et al
Summary
One of the most important gatherings of the world’s economic leaders, the G20 Summit and ministerial meetings, takes place in June, 2019. The Summit presents a valuable opportunity to reflect on the provision and receipt of development assistance for health (DAH) and the role the G20 can have in shaping the future of health financing. The participants at the G20 Summit (ie, the world’s largest providers of DAH, emerging donors, and DAH recipients) and this Summit’s particular focus on global health and the Sustainable Development Goals offers a unique forum to consider the changing DAH context and its pressing questions. In this Health Policy perspective, we examined trends in DAH and its evolution over time, with a particular focus on G20 countries; pointed to persistent and emerging challenges for discussion at the G20 Summit; and highlighted key questions for G20 leaders to address to put the future of DAH on course to meet the expansive Sustainable Development Goals. Key questions include how to best focus DAH for equitable health gains, how to deliver DAH to strengthen health systems, and how to support domestic resource mobilisation and transformative partnerships for sustainable impact. These issues are discussed in the context of the growing effects of climate change, demographic and epidemiological transitions, and a global political shift towards increasing prioritisation of national interests. Although not all these questions are new, novel approaches to allocating DAH that prioritise equity, efficiency, and sustainability, particularly through domestic resource use and mobilisation are needed. Wrestling with difficult questions in a changing landscape is essential to develop a DAH financing system capable of supporting and sustaining crucial global health goals.

When ethics and politics collide in donor-funded global health research

The Lancet
Jul 13, 2019 Volume 394Number 10193p93-186
https://www.thelancet.com/journals/lancet/issue/current

 

Viewpoint
When ethics and politics collide in donor-funded global health research
Katerini T Storeng,
Jennifer Palmer
In this Viewpoint, we share our experience of censorship in evaluation research for global health. Our experience shows a broader trend of donors and implementing partners who deliberately use ethical and methodological arguments to undermine essential research. In a context of chronic underfunding of universities and their growing dependence on donor-driven research grants, we propose several structural and cultural changes to prevent manipulation of research governance systems and to safeguard the independence of research…

To contain Ebola, the United States must fulfil its promise to the World Health Organization

Nature
Volume 571 Issue 7764, 11 July 2019
http://www.nature.com/nature/current_issue.html

 

Editorial | 09 July 2019
To contain Ebola, the United States must fulfil its promise to the World Health Organization
WHO responders are braving bullets to end the outbreak in the Democratic Republic of the Congo, but the virus could cross borders without the pledged funding.

Ethical development of stem-cell-based interventions

Nature Medicine
Volume 25 Issue 7, July 2019
https://www.nature.com/nm/volumes/25/issues/7

 

Perspective | 03 July 2019
Ethical development of stem-cell-based interventions
The clinical translation of stem-cell-based therapeutic interventions has its own ethical and policy challenges requiring collaboration among wide-ranging stakeholders.
Amanda MacPherson  & Jonathan Kimmelman

Ethical development of stem-cell-based interventions

Nature Medicine
Volume 25 Issue 7, July 2019
https://www.nature.com/nm/volumes/25/issues/7

 

Perspective | 03 July 2019
Ethical development of stem-cell-based interventions
The clinical translation of stem-cell-based therapeutic interventions has its own ethical and policy challenges requiring collaboration among wide-ranging stakeholders.
Amanda MacPherson  & Jonathan Kimmelman

Vaccination over Parental Objection — Should Adolescents Be Allowed to Consent to Receiving Vaccines?

New England Journal of Medicine
July 11, 2019 Vol. 381 No. 2
http://www.nejm.org/toc/nejm/medical-journal

 

Perspective
Vaccination over Parental Objection — Should Adolescents Be Allowed to Consent to Receiving Vaccines?
Ross D. Silverman, J.D., M.P.H., Douglas J. Opel, M.D., M.P.H., and Saad B. Omer, M.B., B.S., M.P.H., Ph.D.
…Such cases raise the question of whether adolescent minors should be able to consent to vaccinations without parental permission. For minors to be able to choose to be vaccinated over parental objections, most states would need to make substantive changes to laws governing medical consent. Since children are generally considered nonautonomous under U.S. law, treatment of a child in a medical setting requires parental permission, typically until a child reaches 18 years of age. Parents are generally given broad discretion in making decisions on behalf of their children, in part because they know their child best, are positioned to weigh competing family interests, and are permitted to raise their child as they choose. Such discretion doesn’t mean that adolescents have no role in decisions that affect them, however. Out of respect for adolescents’ developing autonomy, clinicians routinely explore their understanding of health-related issues, solicit their agreement on care plans, navigate discordance between parental and adolescent preferences, and protect adolescents’ confidentiality interests.2
Both ethical principles and state laws also support independent decision making by adolescents in cases in which failing to grant adolescents autonomy could foreseeably result in substantial risk to the minor or to public health. For instance, all states have laws permitting minors to make independent, confidential clinical decisions regarding certain sensitive or stigmatized health care services, such as those related to sexual health, reproduction, mental health, and substance use disorders. Roughly 20% of jurisdictions require adolescents to be at least 12 or 14 years of age to make such decisions; others don’t designate a minimum age of consent.3 A court may also grant an older adolescent (typically 16 years or older) legal emancipation or deem the adolescent to be a “mature minor” who is able to make certain decisions independently.
Most states, however, don’t authorize adolescents to independently consent to vaccination…

A multilevel analysis of the determinants of missed opportunities for vaccination among children attending primary healthcare facilities in Kano, Nigeria: Findings from the pre-implementation phase of a collaborative quality improvement programme

PLoS One
http://www.plosone.org/
[Accessed 13 Jul 2019]

 

Research Article
A multilevel analysis of the determinants of missed opportunities for vaccination among children attending primary healthcare facilities in Kano, Nigeria: Findings from the pre-implementation phase of a collaborative quality improvement programme
Abdu A. Adamu, Olalekan A. Uthman, Muktar A. Gadanya, Olatunji O. Adetokunboh, Charles S. hu
Published: July 10, 2019 https://doi.org/10.1371/journal.pone.0218572

Global thinking on migration, ethnicity, race and health: why essential and what next?

Public Health
Volume 172, Pages A1-A2, 1-152 (July 2019)
https://www.sciencedirect.com/journal/public-health/vol/172/suppl/C

 

Special issue on Migration, Ethnicity, Race and Health
Edited by Laurence Gruer, Fiona Stanaway, Emma Davidson
Editorial No access
Global thinking on migration, ethnicity, race and health: why essential and what next?
R. Bhopal
Pages 83-84

Polio eradication campaign loses ground

Science
12 July 2019 Vol 365, Issue 6449
http://www.sciencemag.org/current.dtl

 

In Depth
Polio eradication campaign loses ground
By Leslie Roberts
Science12 Jul 2019 : 106-107 Restricted Access
Surging cases in Pakistan and Africa have dashed hopes of defeating the virus this year.
Summary
The global initiative to eradicate polio is badly stuck, battling the virus on two fronts. New figures show the wild polio virus remains entrenched in Afghanistan and Pakistan, its other holdout, where cases are surging. The main problem in both countries is that the massive vaccination campaigns held every few months are still not reaching every child. In Africa, meanwhile, the vaccine itself is spawning virulent strains that are hard to contain. The leaders of the world’s biggest public health program are admitting for the first time that success is not just around the corner—and intensively debating how to break the impasse.

Certify reproducibility with confidential data

Science
12 July 2019 Vol 365, Issue 6449
http://www.sciencemag.org/current.dtl

 

Policy Forum
Certify reproducibility with confidential data
By Christophe Pérignon, Kamel Gadouche, Christophe Hurlin, Roxane Silberman, Eric Debonnel
Science12 Jul 2019 : 127-128 Restricted Access
A trusted third party certifies that results reproduce
Summary
Many government data, such as sensitive information on individuals’ taxes, income, employment, or health, are available only to accredited users within a secure computing environment. Though they can be cumbersome to access, such microdata can allow researchers to pursue questions that could not be addressed with only public data (1). However, researchers using confidential data are inexorably challenged with regard to research reproducibility (2). Empirical results cannot be easily reproduced by peers and journal referees, as access to the underpinning data are restricted. We describe an approach that allows researchers who analyze confidential data to signal the reproducibility of their research. It relies on a certification process conducted by a specialized agency accredited by the confidential-data producers and which can guarantee that the code and the data used by a researcher indeed produce the results reported in a scientific paper.

Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor

Science
12 July 2019 Vol 365, Issue 6449
http://www.sciencemag.org/current.dtl

 

Reports
Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor
By Leyuan Ma, Tanmay Dichwalkar, Jason Y. H. Chang, Benjamin Cossette, Daniel Garafola, Angela Q. Zhang, Michael Fichter, Chensu Wang, Simon Liang, Murillo Silva, Sudha Kumari, Naveen K. Mehta, Wuhbet Abraham, Nikki Thai, Na Li, K. Dane Wittrup, Darrell J. Irvine
Science12 Jul 2019 : 162-168 Restricted Access
Vaccine boosting enhances chimeric antigen receptor–T cell immunotherapy for cancer.
A boost for CAR–T cells
Editor’s Summary
Chimeric antigen receptor (CAR)–T cell immunotherapy has been highly successful for treating certain blood cancers. Yet this approach has been a challenge for solid tumors, in part because it is difficult to target functional engineered T cells to the tumor site. Ma et al. designed a vaccine strategy to improve the efficacy of CAR–T cells by restimulating the CAR directly within the native lymph node microenvironment (see the Perspective by Singh and June). Injected “amph-ligand” vaccines promoted synthetic antigen presentation and led to CAR–T cell activation, expansion, and increased tumor killing. The system could potentially be applied to boost any CAR–T cell.
Abstract
Chimeric antigen receptor–T cell (CAR-T) therapy has been effective in the treatment of hematologic malignancies, but it has shown limited efficacy against solid tumors. Here we demonstrate an approach to enhancing CAR-T function in solid tumors by directly vaccine-boosting donor cells through their chimeric receptor in vivo. We designed amphiphile CAR-T ligands (amph-ligands) that, upon injection, trafficked to lymph nodes and decorated the surfaces of antigen-presenting cells, thereby priming CAR-Ts in the native lymph node microenvironment. Amph-ligand boosting triggered massive CAR-T expansion, increased donor cell polyfunctionality, and enhanced antitumor efficacy in multiple immunocompetent mouse tumor models. We demonstrate two approaches to generalizing this strategy to any chimeric antigen receptor, enabling this simple non–human leukocyte antigen–restricted approach to enhanced CAR-T functionality to be applied to existing CAR-T designs.

Influence of health interventions on quality of life in seriously ill children at the end of life: a systematic review protocol

Systematic Reviews
https://systematicreviewsjournal.biomedcentral.com/articles
[Accessed 13 Jul 2019]

 

Protocol
Influence of health interventions on quality of life in seriously ill children at the end of life: a systematic review protocol
Seriously ill children suffer from numerous symptoms at the end of their lives, including pain, anxiety, and restricted communication. There are currently no comprehensive overviews of which health interventions.
Authors: Veerle E. Piette, Joachim Cohen, Luc Deliens, Nele Pauwels, Jutte van der Werff ten Bosch and Kim Beernaert
Citation: Systematic Reviews 2019 8:165
Published on: 11 July 2019

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

Gynecologic Oncology
June 2019 Volume 154, Supplement 1, Page 225
Abandoning the HPV vaccine in Japan due to safety concerns-where is the evidence?
CI Liao, DA Klein, AK Mann, DS Kapp, JK Chan –
Objective: The reported HPV vaccine rates in Japan have dropped from 70% to near zero because of concerns of safety. We proposed to compare the regional and systemic safety profiles of HPV vaccine in Japanese versus whites in a meta-analysis to address these beliefs.

 

Cancer Treatment Reviews
Volume 78, August 2019, Pages 8-16
Anti-Tumour Treatment
The Promise of Combining Cancer Vaccine and Checkpoint Blockade for Treating HPV-Related Cancer
T Shibata, BJ Lieblong, T Sasagawa, M Nakagawa – 2019
Highlights
:: HPV have ingenious immune suppressive mechanisms.
:: Checkpoint inhibitors have little efficacy against HPV-associated cancers.
:: HPV therapeutic vaccines have little efficacy against HPV-associated cancers.
:: However, combining these two therapeutic modalities is starting to show promise.
:: Epitope spreading may play a critical role mechanistically in this combination.

Media/Policy Watch

Media/Policy Watch
This watch section is intended to alert readers to substantive news, analysis and opinion from the general media and selected think tanks and similar organizations on vaccines, immunization, global public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.
We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.

 

The Atlantic
http://www.theatlantic.com/magazine/
Accessed 13 Jul 2019
Health
What the Measles Epidemic Really Says About America
The return of a vanquished disease reflects historical amnesia, declining faith in institutions, and a troubling lack of concern for the public good.
Peter Beinart
August 2019 Issue

 

BBC
http://www.bbc.co.uk/
Accessed 13 Jul 2019
[No new, unique, relevant content]

 

The Economist
http://www.economist.com/
Accessed 13 Jul 2019
Global
Are social media to blame for a decline in vaccine uptake?
July 03, 2019 Professor David Salisbury
England’s health minister thinks that social media companies should be forced to remove false information about vaccines, but Professor David Salisbury, associate fellow at the Centre on Global Health Security, Chatham House, London, says other factors are at play around vaccine uptake

 

Financial Times
http://www.ft.com/home/uk
Accessed 13 Jul 2019
[No new, unique, relevant content]

 

Forbes
http://www.forbes.com/
Accessed 13 Jul 2019
[No new, unique, relevant content]

 

Foreign Affairs
http://www.foreignaffairs.com/
Accessed 13 Jul 2019
[No new, unique, relevant content]

Foreign Policy
http://foreignpolicy.com/
Accessed 13 Jul 2019
[No new, unique, relevant content]

 

The Guardian
http://www.guardiannews.com/
Accessed 13 Jul 2019
Vaccines and immunisation
‘Worry is contagious’: the vaccine-hesitant parents putting children at risk
More than committed anti-vaxxers, parents who are unsure about vaccination are one of the top 10 threats to global health this year. What’s behind this crisis of confidence?
Hattie Garlick Sat 13 Jul 2019 05.01 EDT

 

New Yorker
http://www.newyorker.com/
Accessed 13 Jul 2019
[No new, unique, relevant content]

 

New York Times
http://www.nytimes.com/
Accessed 13 Jul 2019
Business
Johnson & Johnson to Test Experimental HIV Vaccine in U.S., Europe
Johnson & Johnson said on Friday it plans to conduct a late-stage study of its investigational vaccine for Human Immunodeficiency Virus (HIV) in several countries across the Americas and Europe, including the United States.
By Reuters
July 12

 

Washington Post
http://www.washingtonpost.com/
[No new, unique, relevant content]

Think Tanks et al

Think Tanks et al

Brookings
http://www.brookings.edu/
Accessed 13 Jul 2019
[No new relevant content]

 

Center for Global Development
http://www.cgdev.org/page/press-center
[No new relevant content]

 

CSIS
https://www.csis.org/
Accessed 13 Jul 2019
[No new relevant content]

 

Council on Foreign Relations
http://www.cfr.org/
Accessed 13 Jul 2019
[No new relevant content]

 

Kaiser Family Foundation
https://www.kff.org/search/?post_type=press-release
Accessed 13 Jul 2019
[No new relevant content]