Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Final Report

New England Journal of Medicine
August 1, 2019 Vol. 381 No. 5
http://www.nejm.org/toc/nejm/medical-journal

 

Original Articles
Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Final Report
R.M. Casey and Others
Conclusions
A fractional dose of the 17DD yellow fever vaccine was effective at inducing seroconversion in participants who were seronegative at baseline. Titers remained above the threshold for seropositivity at 1 year after vaccination in nearly all participants who were seropositive at 1 month after vaccination. These findings support the use of fractional-dose vaccination for outbreak control. (Funded by the U.S. Agency for International Development and the Centers for Disease Control and Prevention.)