Revisiting the Correlate of Reduced HIV Infection Risk in the Rv144 Vaccine Trial

Journal of Virology
September 2019; Volume 93,Issue 17
http://jvi.asm.org/content/current

 

Commentary
Revisiting the Correlate of Reduced HIV Infection Risk in the Rv144 Vaccine Trial
The RV144 vaccine trial is the only clinical study to have shown a modest but statistically significant decrease in HIV infection risk. RV144 and the subsequent studies identifying the level of V1V2-specific antibodies as a correlate of reduced infection risk are still controversial despite many papers supporting and expanding the initial study.