Emergencies

Emergencies

Ebola – DRC+
Public Health Emergency of International Concern (PHEIC)

No regular weekly updates identified.

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Ridgeback Biotherapeutics LP announces receipt of Breakthrough Therapy designation from FDA for mAb114
MIAMI, Sept. 6, 2019 /PRNewswire/ — Ridgeback Biotherapeutics LP, a closely held biotechnology company, today announced that the Food and Drug Administration has recently granted mAb114, an experimental treatment for Ebola, Breakthrough Therapy designation…

“The FDA’s decision to grant mAb114 Breakthrough Therapy designation for the treatment of Ebola reflects a recognition of the promising efficacy and safety data that has been collected to date for this investigational drug.  We plan to work closely with the FDA as we continue to advance our development program for mAb114.  The substantial survival improvement seen with mAb114 in the PALM trial catalyzed this important regulatory milestone.  We are grateful to our PALM partners for all of their help in advancing treatments for Ebola patients and our ultimate gratitude goes to the study’s participants and their families.  Their trust and support will change the course of this disease,” said Wendy Holman, CEO of Ridgeback Biotherapeutics.

About Pamoja Tulinde Maisha (PALM):
The PALM study is co-sponsored and funded by the INRB (Institut National de Recherche Biomédicale) and the National Institute of Allergy and Infectious Diseases (NIAID) of the US National Institutes of Health and carried out by an international research consortium coordinated by the World Health Organization (WHO).  The Ebola treatment centers in the PALM trial have been overseen by staff from the Institut National de Recherche Biomédicale (INRB); the DRC Ministry of Health; and three medical humanitarian organizations:  the Alliance for International Medical Action (ALIMA), the International Medical Corps (IMC), and Médicins Sans Frontières (MSF). 

About mAb114:
mAb114 is a monoclonal antibody — a protein that binds to a single target on a pathogen — isolated from a human survivor of the 1995 Ebola outbreak in Kikwit, a city in the DRC…

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POLIO
Public Health Emergency of International Concern (PHEIC)

Polio this week as of 28 August 2019
:: The Technical Advisory Group on Polio Eradication in Pakistan met on 29 – 30 August to discuss the challenges faced by the programme and propose recommendations for transforming key aspects in the programme strategy for polio eradication.
:: An Investment case has been launched in order to ensure the GPEI’s funding requirements are fully financed until eradication and certification.
[See Milestones above for detail]
:: The August Polio News with the latest news, polio in numbers and funding updates is now available.

Summary of new viruses this week:
:: Afghanistan — two wild poliovirus type 1 (WPV1) cases,
:: Myanmar – one circulating vaccine-derived poliovirus type 1 (cVDPV1) case,
:: Angola – two circulating vaccine-derived poliovirus type 2 (cVDPV2) cases,
:: Ethiopia – one cVDPV2 case;
:: Democratic Republic of the Congo – six (cVDPV2 cases).

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Editor’s Note:
WHO has posted a refreshed emergencies page which presents an updated listing of Grade 3,2,1 emergencies as below.

WHO Grade 3 Emergencies [to 7 Sep2019]

Democratic Republic of the Congo
:: Local vaccinators build trust in Beni, the Democratic Republic of the Congo
2 September 2019 Vaccination team 29 is composed entirely of Congolese health workers

Syrian Arab Republic
:: WHO statement on attacks against health care in north-west Syria 2 September 2019

Nigeria – No new digest announcements identified
Mozambique floods – No new digest announcements identified
Somalia – No new digest announcements identified
South Sudan – No new digest announcements identified
Yemen – No new digest announcements identified

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WHO Grade 2 Emergencies [to 7 Sep2019]

Cameroon – No new digest announcements identified
Libya – No new digest announcements identified
MERS-CoV
:: WHO statement on the tenth meeting of the IHR Emergency Committee regarding MERS
3 September 2015

Afghanistan – No new digest announcements identified
Angola – No new digest announcements identified
Burkina Faso [in French] – No new digest announcements identified
Burundi – No new digest announcements identified
Central African Republic – No new digest announcements identified
Ethiopia – No new digest announcements identified
HIV in Pakistan – No new digest announcements identified
Iran floods 2019 – No new digest announcements identified
Iraq – No new digest announcements identified
Malawi floods – No new digest announcements identified
Measles in Europe – No new digest announcements identified
Myanmar – No new digest announcements identified
Niger – No new digest announcements identified
occupied Palestinian territory – No new digest announcements identified
Sudan – No new digest announcements identified
Ukraine – No new digest announcements identified
Zimbabwe – No new digest announcements identified

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WHO Grade 1 Emergencies [to 7 Sep2019]

Chad – No new digest announcements identified
Djibouti – No new digest announcements identified
Kenya – No new digest announcements identified
Mali – No new digest announcements identified
Namibia – viral hepatitis – No new digest announcements identified
Tanzania – No new digest announcements identified

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UN OCHA – L3 Emergencies
The UN and its humanitarian partners are currently responding to three ‘L3’ emergencies. This is the global humanitarian system’s classification for the response to the most severe, large-scale humanitarian crises. 
Syrian Arab Republic
:: Syrian Arab Republic: Recent Developments in Northwestern Syria Situation Report No. 11 – as of 6 September 2019

Yemen – No new digest announcements identified

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UN OCHA – Corporate Emergencies
When the USG/ERC declares a Corporate Emergency Response, all OCHA offices, branches and sections provide their full support to response activities both at HQ and in the field.
Editor’s Note:
Ebola in the DRC has bene added as a OCHA “Corporate Emergency” this week:
CYCLONE IDAI and Kenneth – No new digest announcements identified
EBOLA OUTBREAK IN THE DRC – No new digest announcements identified

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