Current Opinion in Infectious Diseases
October 2019 – Volume 32 – Issue 5
WHO’s new rabies recommendations: implications for high incidence countries
Pattanaik, Amrita; Mani, Reeta S.
Current Opinion in Infectious Diseases. 32(5):401-406, October 2019.
Recent findings The key changes in the updated WHO 2018 guidelines for rabies prophylaxis include abbreviated vaccination regimens for pre and postexposure prophylaxis. These cost and dose-sparing regimens allow equitable sharing of vaccines, necessitate fewer clinic visits and thus can enhance patient compliance. The recommendations on rabies immunoglobulin administration permit prioritization and optimal use of this life-saving biologic, especially in areas with scarcity. However, there is a need for additional evidence to support the abridgment of some regimens and need for data on the safety and immunogenicity of these regimens in special groups such as infants and the immunocompromised.