October 22/29, 2019, Vol 322, No. 16, Pages 1527-1620
Pay-to-Participate Trials and Vulnerabilities in Research Ethics Oversight
Holly Fernandez Lynch, JD, MBE; Steven Joffe, MD, MPH
JAMA. 2019;322(16):1553-1554. doi:10.1001/jama.2019.14703
This Viewpoint discusses ethical considerations surrounding randomized clinical trials (RCTs) funded by patients who pay to enroll in them, and gaps in IRB oversight that could allow the trials to be approved despite possible patient exploitation and questionable scientific quality and social value.