The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases

EMBO Reports
Volume 20 Issue 11 5 November 2019
https://www.embopress.org/toc/14693178/current

 

Opinion 21 October 2019
The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases
João Pedro de Magalhães, Jingwei Wang
A major task for genetics is searching for genetic variants associated with disease. But we may well be missing a large number of “unknown unknown” alleles in the “fog of genetics”.