CDC/ACIP [to 16 Nov 2019]
Thursday, November 14, 2019
Transcript of November 13, 2019, AR Threats Report – Tele-briefing
Wednesday, November 13, 2019
More People in the United States Dying from Antibiotic-Resistant Infections than Previously Estimated
[See Milestones above for detail]
MMWR News Synopsis for Friday, November 15, 2019
Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, January 2018–June 2019
Stopping current outbreaks and limiting the risk of vaccine-derived poliovirus (VDPV) emergence requires increasing assistance to type-2-circulating VDPV outbreak countries; using a novel, stabilized monovalent type 2 oral polio virus in the future; maintaining high population immunity in all countries; and ending all live, attenuated oral poliovirus vaccine use after certification of polio eradication.
In under-immunized populations, strains of poliovirus in oral poliovirus vaccine (OPV) can circulate and mutate to behave like wild poliovirus, leading to outbreaks of paralytic poliomyelitis. During January 2018–June 2019, the number of circulating vaccine-derived poliovirus (cVDPV) outbreaks increased from nine to 29 during January 2017–June 2018. Of these, 86% were caused by cVDPV type 2 that occurred both inside and outside monovalent type 2 OPV outbreak response areas. Global OPV immunization after April 2016 only contained types 1 and 3 strains.
Progress Toward Poliomyelitis Eradication — Pakistan, January 2018–September 2019
Despite earlier progress, interruption of wild polio virus type 1 (WPV1) circulation in Pakistan failed in 2018-2019. Pakistan’s polio program has identified key gaps to address, including multiple managerial and operational challenges and reversing negative community perceptions of polio vaccination. Stopping WPV1 transmission in Pakistan will require sustained, quality implementation of eradication activities with a renewed sense of urgency.
Pakistan and Afghanistan are the only countries that continue to confirm ongoing wild poliovirus type 1 (WPV1) transmission. Despite reporting 12 cases in 2018, an increase to 80 cases as of Nov. 2019 shows that polio eradication efforts in Pakistan failed to interrupt transmission. The Pakistan Polio Eradication program has identified key gaps that need to be addressed, and national leadership has committed to making transformative changes. Pakistan’s program management, supervision and oversight in core transmission areas must be strengthened to support vaccination efforts and allow access to chronically missed children. Fully engaging communities and addressing resistance to vaccination will help rebuild trust and restore progress toward WPV1 elimination in Pakistan. WPV1 transmission can be interrupted in Pakistan, but it will require full and rapid implementation of recommendations.