Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Science Translational Medicine
27 November 2019 Vol 11, Issue 520
https://stm.sciencemag.org/

 

Research Articles
Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile
By Pilar Garcia-Broncano, Shivaali Maddali, Kevin B. Einkauf, Chenyang Jiang, Ce Gao, Joshua Chevalier, Fatema Z. Chowdhury, Kenneth Maswabi, Gbolahan Ajibola, Sikhulile Moyo, Terence Mohammed, Thabani Ncube, Joseph Makhema, Patrick Jean-Philippe, Xu G. Yu, Kathleen M. Powis, Shahin Lockman, Daniel R. Kuritzkes, Roger Shapiro, Mathias Lichterfeld
Science Translational Medicine27 Nov 2019 Full Access
Antiretroviral treatment initiation immediately after birth reduces HIV-1 viral reservoir size and alters innate immune responses in neonates.