Dengue pre-vaccination serology screening for the use of Dengvaxia®

Journal of Travel Medicine
Volume 26, Issue 8, 2019


Dengue pre-vaccination serology screening for the use of Dengvaxia®
Elizabeth Hunsperger, PhD, Rosanna Peeling, PhD, Duane J Gubler, DSc, Eng Eong Ooi, BMBS, PhD
J Travel Med, Volume 26, Issue 8, 2019, taz092,
Can pre-vaccination screening for prior dengue infection using commercially available rapid diagnostic tests guide Dengvaxia administration?
Dengue is a global problem with an estimated 100 million symptomatic cases worldwide every year.1 Endemic throughout the tropics, this disease is expanding into the subtropics in the geographic footprint of its mosquito vectors, principally Aedes aegypti. This acute disease that presents with syndromes ranging from undifferentiated febrile illness to circulatory shock from vasculopathy, hemorrhage and organ dysfunction is caused by four closely related but antigenically distinct dengue viruses (DENV1–4). Epidemiological observations have found that certain strains of DENV are associated with increased epidemic potential and severe disease2 Moreover, elevated risk…