Nature Reviews Drug Discovery
Volume 19 Issue 4, April 2020
Review Article | 14 February 2020
Next-generation influenza vaccines: opportunities and challenges
Current seasonal influenza vaccines lack efficacy against drifted or pandemic virus strains, and the development of novel vaccines that elicit broader immunity represents a public health priority. Here, Nabel and colleagues discuss approaches to improve vaccine efficacy which harness new insights from influenza antigen structure and human immunity, highlighting major targets, vaccines in development and ongoing challenges.
Chih-Jen Wei, Michelle C. Crank[…] & Gary J. Nabel