Science Translational Medicine
22 April 2020 Vol 12, Issue 540
https://stm.sciencemag.org/

Perspective
The evidence landscape in precision medicine
By Spencer Phillips Hey, Cory V. Gerlach, Garrett Dunlap, Vinay Prasad, Aaron S. Kesselheim
Science Translational Medicine22 Apr 2020 Restricted Access
Abstract
Precision medicine is beginning to make an impact on the treatment of different diseases, but there are still challenges that must be overcome, such as the complexity of interventions, the need for marker validation, and the level of evidence necessary to demonstrate effectiveness. In this Perspective, we describe how evidence landscapes can help to address these challenges.