Nature Reviews Immunology
Volume 20 Issue 6, June 2020
Review Article | 04 March 2020
Defining trained immunity and its role in health and disease
Here a group of leaders in the field define our current understanding of ‘trained immunity’, which refers to the memory-type responses that occur in the innate immune system. The authors discuss our current understanding of the key epigenetic and metabolic processes involved in trained immunity and consider its relevance in immune-mediated diseases and cancer.
Mihai G. Netea, Jorge Domínguez-Andrés[…] & Eicke Latz