June 9, 2020, Vol 323, No. 22, Pages 2231-2350
When Should Clinicians Act on Non–Statistically Significant Results From Clinical Trials?
Paul J. Young, PhD, MBChB; Christopher P. Nickson, MBChB; Anders Perner, MD, PhD
JAMA. 2020;323(22):2256-2257. doi:10.1001/jama.2020.3508
This Viewpoint discusses considerations that might lead physicians to change their practice based on RCTs reporting non–statistically significant differences in primary outcomes, including trial methodology, totality of evidence, cost, invasiveness, and labor-intensiveness of the interventions being compared.
Audio Interview: When Should Physicians Act on Non–Statistically Significant Results From Clinical Trials?