Nature Reviews Drug Discovery
Volume 19 Issue 9, 1 September 2020
Perspective | 06 August 2020
Antitumour dendritic cell vaccination in a priming and boosting approach
Dendritic cell vaccines have been widely investigated as a type of cancer immunotherapy, but their promise has not yet been realized. Kandalaft and colleagues propose that a prime and boost approach — primed with either standard therapies or dendritic cell vaccines and boosted with a personalized synthetic vaccine — could help fulfil the potential of such vaccines. They discuss improvements in dendritic cell vaccines that have enabled prime–boost approaches, as well as challenges for adoption.
Alexandre Harari, Michele Graciotti[…] & Lana E. Kandalaft