Annals of Internal Medicine
6 October 2020 Volume 173, Issue 7
Medicine and Public Issues
Institutional Review Board Quality, Private Equity, and Promoting Ethical Human Subjects Research
Holly Fernandez Lynch, JD, MBE and Stephen Rosenfeld, MD, MBA
Several U.S. senators have raised concerns about the growing trends of private equity ownership and consolidation of for-profit institutional review boards (IRBs). This article summarizes the challenges in assessing IRB quality, explores the pros and cons of the for-profit and nonprofit IRB models, and presents a new model of IRB oversight.